Senior Principal Scientist, Cancer Cell Programs

16 hours ago


La Jolla, California, United States Pfizer Full time
ROLE SUMMARY

Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in cancer cell biology into novel therapeutics.

Key Responsibilities
  • Lead preclinical research with a collaborative team of scientists to advance clinical and pre-clinical drug programs in cancer cell biology.
  • Develop innovative strategies for understanding the role of cell signaling and/or cell cycle targets in cancer progression, drug resistance, and immune modulation.
  • Provide scientific leadership and serve as biology lead for post-candidate programs in cross-functional Global Product Teams to support asset clinical development.
  • Interface with discovery biology, discovery technologies, computational biology, in vivo pharmacology, drug pharmacokinetics, and drug safety to design experiments and interpret datasets.
  • Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base, and cancer biology expertise.
Qualifications
  • PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology, or a comparable biological science with 7+ years of relevant postdoctoral experience.
  • Expertise in cell signaling and/or cell cycle biology as evidenced by publication in peer-reviewed journals.
  • Strong ability to multi-task, lead biology research activities across multiple programs, and collaborate with different partner lines.
Preferred Qualifications
  • Experience in leading preclinical translational oncology research and working with cross-functional clinical development teams.
  • Knowledge of other areas of cancer biology and relevant clinical landscape, including oncogenic signaling, DNA repair, cancer epigenetics, and ADC biology.
  • Managerial experience, preferably in an industry setting.


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