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Lead Platform Architect
2 months ago
About Karius
Karius is a pioneering life science startup dedicated to revolutionizing the diagnosis of infectious diseases. By integrating Next-Generation Sequencing with advanced data analytics, we can detect over 1,000 human pathogens from a single blood sample, typically within one business day. Our innovative approach to analyzing microbial cell-free DNA empowers healthcare professionals to address their most complex cases swiftly, with aspirations to enhance clinical trials, uncover new microbes, and alleviate patient suffering globally.
Position Overview
The research, development, and operational success of Karius's groundbreaking technologies are fundamentally reliant on robust computing and data infrastructure, software architecture, and a suite of research and engineering tools (collectively referred to as the Karius R&D/Ops platform or simply the "Platform"). In this vital engineering position, you will work in close collaboration with the engineering and scientific leadership to define the strategic vision for the technology underpinning this Platform. Subsequently, you will formulate and execute a technology roadmap aimed at creating and maintaining a scalable, secure, and reliable Platform.
Why Karius?
Karius's mission is to combat infectious diseases through advancements in genomic sequencing and machine learning. Our platform provides unparalleled insights into the microbial environment, equipping clinicians with a comprehensive testing solution capable of identifying over a thousand pathogens directly from blood samples. Throughout our journey, we have consistently pushed the boundaries of innovation to extract critical insights from microbial cell-free DNA. As a key member of one of Karius's most forward-thinking teams, you will have the opportunity to influence and enhance essential components of our core engineering platform, directly impacting patients affected by infectious diseases and beyond.
Reporting Structure
Reports to the Vice President of Engineering.
Key Responsibilities
• Spearheading architectural initiatives from inception to completion, ensuring timely execution while adhering to budgetary and quality standards.
• Crafting architectural frameworks, blueprints, and guidelines for the development and operation of the Platform.
• Guaranteeing that the architecture fulfills both technical and business requirements, including security, performance, interoperability, and scalability.
• Keeping abreast of industry trends and emerging technologies to ensure the Platform utilizes optimal solutions.
• Clearly articulating and presenting complex concepts to both technical and non-technical stakeholders.
• Creating, documenting, and organizing strategic artifacts such as technical proposals, designs, and risk assessments.
• Ensuring that Karius's R&D and engineering teams have access to the necessary infrastructure, tools, and processes for optimal productivity.
• Ensuring the Karius Platform is cloud vendor agnostic, globally provisionable using a blueprint as code, and compliant with regional privacy and security regulations.
• Facilitating the provisioning of the Platform for external laboratories, enabling them to utilize Karius products.
Job Highlights
Karius operates at the forefront of what is achievable in infectious disease diagnostics. This role presents a plethora of exciting challenges and opportunities. To deliver value, you will engage with cutting-edge technologies, architecting solutions where existing options fall short of meeting our complexity and scale. If you thrive on building sophisticated distributed systems while navigating unique challenges, you will find this role rewarding. Ultimately, this position carries significant technical and organizational influence, enhancing the knowledge and capabilities of Karius's engineering, scientific, and operational teams through innovative Platform developments.
Travel Requirements
Travel may be required up to 10%.
Physical Demands
Position involves extended periods of sitting and standing, visual monitoring, and exposure to moderate noise levels. Work is conducted in an office environment.
Qualifications
We seek candidates who have successfully designed and managed multiple complex, high-quality, regulated, reliable, and scalable cloud-native platforms. Demonstrated technical, interpersonal, and organizational skills to translate intricate business and technical requirements into a unique platform that serves as a sustainable competitive advantage for Karius are essential.
• B.S. or M.S. in Computer Science, Electrical Engineering, Physics, Statistics, Biomedical Engineering, Genetics, or a related field. A Ph.D. is a significant advantage.
• 15+ years of engineering experience, with at least 10 years in leading the development and operation of distributed software systems and cloud-native platforms.
• Expertise in infrastructure-as-code design and tools such as Terraform.
• In-depth knowledge and experience in design patterns, implementation, testing, and failure management of distributed systems and microservices.
• Practical experience with cloud-native software development and operations, utilizing tools and technologies such as Docker, Kubernetes, and cloud services for software services and data analytics.
• Proficiency in industry security standards such as NIST CSF/SSDF, with hands-on experience in implementing and monitoring cloud security controls.
• Familiarity with various code flow and DevOps methodologies, including gitOps.
• Proven track record of building trust, exerting cross-functional influence, and leading organizational change.
• Ability to articulate and present complex ideas effectively to diverse audiences.
• Experience in the healthcare and life sciences sectors, particularly in developing medical devices, is a considerable plus.
Personal Attributes
We are looking for a humble, inquisitive, and collaborative individual to join our team. At Karius, we highly value deep domain expertise, a passion for innovation, a collaborative spirit, and a commitment to solving challenging problems that have a meaningful impact on the world. A sense of ownership and accountability is essential for fostering a productive and high-performing team. If you resonate with our vision, we would be delighted to consider you for this role.
Karius is committed to fostering a diverse and inclusive workplace, providing equal employment opportunities for all applicants and employees. We honor and invest in the full diversity of people in our hiring, recruiting, and employee development processes. All qualified applicants will be considered without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, citizenship, disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by law.
