Senior Bioinformatics Engineer
7 days ago
The Simons Foundation is seeking a highly skilled Senior Bioinformatics Engineer to join our team. As a key member of our Bioinformatics team, you will play a critical role in returning genetic results to thousands of SPARK participants, including ASD and secondary health-related variants. You will work with petabytes of genomics data and develop workflows for a variety of informatics needs across SFARI.
Key Responsibilities:- Manage the bioinformatics portion of the return of genetic results process, including delivery of sequencing data, variant analysis, and clinical validation orders
- Track data deliveries of samples sent for sequencing
- Run quality control pipeline to confirm RoR eligibility
- Run variant filtering and annotation pipelines for SNVs/Indels & CNVs
- Coordinate lab confirmation orders for predicted pathogenic variants
- Analyze and summarize statistics for sequencing batches
- Respond to questions from SPARK or lab related to variant predictions/orders
- Master's degree in bioinformatics, computational biology, or related field
- At least 4+ years of relevant work experience
- Strong Python skills and software development best practices
- Experience with sequencing data (whole exome or whole genome) and related tools
- Experience performing reproducible data analysis
- Experience working in an HPC environment
- Experience with git/github
- Effective oral and written communicator
- Ability to thrive in collaborative environments
- Project management experience
- Experience analyzing large research datasets (>10,000 individuals)
- Familiarity with core genetics concepts
- Solid understanding of statistical analysis
- Experience generating interactive data visualizations or dashboards
- Desire to continually learn and stay up-to-date with best practices and the latest methods
- The full-time annual compensation range for this position is $150,000 - $175,000, depending on experience
- In addition to competitive salaries, the Simons Foundation provides employees with an outstanding benefits package
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