Senior Bioinformatics Engineer

7 days ago


New York, New York, United States Simons Foundation Full time
Job Title: Senior Bioinformatics Engineer

The Simons Foundation is seeking a highly skilled Senior Bioinformatics Engineer to join our team. As a key member of our Bioinformatics team, you will play a critical role in returning genetic results to thousands of SPARK participants, including ASD and secondary health-related variants. You will work with petabytes of genomics data and develop workflows for a variety of informatics needs across SFARI.

Key Responsibilities:
  • Manage the bioinformatics portion of the return of genetic results process, including delivery of sequencing data, variant analysis, and clinical validation orders
  • Track data deliveries of samples sent for sequencing
  • Run quality control pipeline to confirm RoR eligibility
  • Run variant filtering and annotation pipelines for SNVs/Indels & CNVs
  • Coordinate lab confirmation orders for predicted pathogenic variants
  • Analyze and summarize statistics for sequencing batches
  • Respond to questions from SPARK or lab related to variant predictions/orders
Requirements:
  • Master's degree in bioinformatics, computational biology, or related field
  • At least 4+ years of relevant work experience
  • Strong Python skills and software development best practices
  • Experience with sequencing data (whole exome or whole genome) and related tools
  • Experience performing reproducible data analysis
  • Experience working in an HPC environment
  • Experience with git/github
  • Effective oral and written communicator
  • Ability to thrive in collaborative environments
Preferred Qualifications:
  • Project management experience
  • Experience analyzing large research datasets (>10,000 individuals)
  • Familiarity with core genetics concepts
  • Solid understanding of statistical analysis
  • Experience generating interactive data visualizations or dashboards
  • Desire to continually learn and stay up-to-date with best practices and the latest methods
What We Offer:
  • The full-time annual compensation range for this position is $150,000 - $175,000, depending on experience
  • In addition to competitive salaries, the Simons Foundation provides employees with an outstanding benefits package


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