Senior Molecular Biologist, Gene Therapy Development

3 weeks ago

Columbus, Ohio, United States Forge Biologics Full time
About the Role

**Job Summary**

We are seeking a highly skilled Scientist II, Analytical Development and Optimization to join our team at Forge Biologics. As a key member of our Analytical Development group, you will play a critical role in driving the development of our in-house programs and client projects.

Key Responsibilities

  • Design and execute cell culture experiments and bioanalytical assays to support manufacturing, purification, and clinical comparability of AAV gene therapy products.
  • Develop and optimize analytical assays, including DNA/RNA isolation, qPCR, RT-qPCR, ddPCR, ELISA, SDS-PAGE, and Western Blot.
  • Perform AAV infectivity titration and neutralization assays.
  • Write and review formal reports, including method SOPs, reports, and other technical documents.
  • Collaborate with cross-functional stakeholders, including Process Development, Product Development, and Quality Control, to advance AAV vector production portfolios.
  • Participate in project-related teams and internal/external collaborations.
  • Maintain a clean and fully functional laboratory, adhering to all laboratory standards as defined in SOPs.
  • Ensure timely resolution of scientific and technical challenges.
  • Contribute to a safe, efficient, and effective environment with personal accountability.
  • Lead, mentor, and inspire junior team members.

Requirements

  • PhD in Molecular Biology, Biotechnology, Biochemistry, Immunology, Virology, or a related field with 0-2+ years of relevant experience, or MS with 6+ years of related experience in assay development.
  • Experience with aseptic techniques in mammalian cell culture systems and performing bioassays.
  • Technical proficiency in quantitative PCR.
  • Experience in gene therapy and/or vaccine testing is preferred.
  • Prior experience performing viral genome titer, infectivity, potency, host cell protein, and host cell DNA assays is preferred.
  • Experience with ddPCR, ELISA, SDS-PAGE, and Western Blot is preferred.
  • Knowledge of analytical ultracentrifugation techniques is desirable.
  • Excellent written and verbal communication skills.
  • Ability to work independently and collaboratively, as required, in a fast-paced, matrixed team environment consisting of internal and external team members.
  • Ability to work with a high attention to detail with minimal supervision.
  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization, and time management skills, including the ability to support and prioritize multiple projects at various stages of development.
  • Proven record of successfully planning experiments and executing projects in collaboration with internal or external stakeholders.

Work Environment and Physical Demands

This position works in both a laboratory environment and typical office environment, where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area.

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