DNA-encoded Library Researcher
5 days ago
Job Overview
Absorb your expertise in chemistry and lead the development of our DNA-encoded library platform. Work with cross-functional teams to enhance our DEL chemistry capabilities and contribute to AbbVie's mission to deliver innovative medicines.
About the Job
We're seeking a highly skilled scientist to join our team at AbbVie Headquarters in Lake County, Illinois. As a Senior Scientist II or Principal Research Scientist I, you'll be responsible for designing and developing DEL synthesis schemes, supervising on-DNA chemistry strategies, and collaborating with medicinal chemistry teams.
Responsibilities
- DEL Chemistry Development: Design and develop DEL synthesis schemes with high structural diversity using robust chemistry.
- On-DNA Chemistry Strategies: Supervise efforts to develop, validate, and implement innovative on-DNA chemistry strategies, providing technical supervision and expertise as required.
- Collaboration with Medicinal Chemistry Teams: Interface with Medicinal Chemistry teams to enhance the DEL library portfolio, hit expansion strategy, and hit confirmation activities.
- Data Analysis and Computational Tools: Contribute to the development of computational tools and methodologies to strengthen our DEL data analysis platform and support hit generation activities across AbbVie's therapeutic area portfolio.
- Platform Strategy: Contribute to the direction and evolution of AbbVie's DEL platform strategy.
Requirements
- Education: BS, MS, or Ph.D. in Computational Chemistry, Medicinal Chemistry, or related discipline.
- Experience: Typically 4-6+ years (PhD), 10-12+ years (MS), or 12-14+ years (BS) of experience in all aspects of the DNA-encoded Library platform.
- Skills: In-depth knowledge and experience in library design, DEL selections, next-generation sequencing (NGS), data analysis, DEL hit confirmation strategies, modern cheminformatics tools, computational tools, data visualization, and statistical analysis of large data sets.
- Leadership Skills: Proven track record of scientific publications successfully applying DEL technology for hit generation against targets of pharmaceutical relevance, demonstrable effective leadership skills, and a high level of professionalism in working with internal and external collaborators.
Salary Range: The estimated salary range for this position is $120,000 - $180,000 per year, depending on qualifications and experience.
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