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Lead Scientist in Protein Engineering

2 months ago

Canton, Ohio, United States Pledge Therapeutics Full time

Position: Senior Scientist, Protein Purification & Expression

Location: Canton MA

Company Overview:

Pledge Therapeutics is a pioneering start-up committed to enhancing treatments in the fields of immunology, oncology, and virology. Our mission is to create innovative therapies that significantly improve patient outcomes. Utilizing our advanced discovery platform, we have successfully developed high-quality, preclinical drug candidates targeting various promising drug pathways that have the potential to revolutionize current treatment methodologies.

Position Overview:

We are in search of a dedicated and proficient scientist to spearhead efforts in protein purification, production, and characterization within our Rapid Response Group (RRG), a specialized unit in our Discovery Division. The RRG adopts a hands-on, mission-driven approach, engaging in high-impact projects to develop essential tools, methodologies, and data that bolster our therapeutic initiatives. The ideal candidate will play a pivotal role in this distinguished team, advancing research on protein targets and therapeutic development. This position is vital to our R&D objectives, directly impacting our success by addressing protein-related challenges and facilitating the transition of groundbreaking discoveries into viable therapeutics.

Key Responsibilities:

  • Develop and refine protein expression systems, concentrating on baculovirus (insect cell) and/or mammalian systems, and execute sub-cloning as necessary to support these initiatives.
  • Design and implement innovative purification protocols to tackle technical challenges, leveraging a profound understanding of molecular biology and biochemistry.
  • Troubleshoot and enhance protein expression and purification strategies, ensuring high-quality protein production through sophisticated chromatographic and filtration techniques.
  • Analyze experimental data, assist in scale-up processes, and drive continuous improvement while ensuring compliance with timelines in a dynamic, fast-paced environment.
  • Collaborate across functions with teams in immuno-oncology, virology, and structural biology, sharing expertise to improve our capacity to work with a diverse array of proteins.

Qualifications:

  • PhD in Biochemistry, Cell Biology, or a related discipline; exceptional MS candidates may be considered.
  • 5-7 years of pertinent experience in a dynamic, fast-paced setting.
  • Expertise in construct design, sub-cloning, and protein purification, with experience covering the entire protein production pipeline, from gene design to characterization.
  • Extensive knowledge and hands-on experience with various protein expression systems, particularly baculovirus and/or mammalian expression, demonstrated by a history of prior work across different protein classes.
  • Experience in purifying biologics using techniques such as affinity chromatography (e.g., Protein A/G/L, Ni-NTA), ion exchange, size exclusion, and hydrophobic interaction chromatography.
  • Proficiency in analytical techniques such as SDS-PAGE, HPLC or UHPLC, and other relevant analytical methods.
  • Excellent troubleshooting skills, strong analytical capabilities, meticulous attention to detail, and outstanding organizational skills.
  • High degree of independence, intellectual capacity, and initiative.
  • Strong work ethic and adaptability, with the ability to multitask and maintain a positive attitude as R&D priorities evolve.

Employment Type: Full-time, Work Permit, Equal Opportunity Employment.