Director of Vector Production

2 weeks ago


Richmond, Virginia, United States Sangamo Therapeutics Full time
Job Summary

The Director of Vector Production will oversee the development and production of recombinant Adeno-associated Viral Vectors (rAAV) at Sangamo Therapeutics. This role will manage the process development, testing, and fill finish of rAAV products at contract manufacturing organizations (CMOs) and internal activities related to scale-up and production of rAAVs in-house.

Key Responsibilities
  1. Manage the process development, GMP production, testing, and fill finish of rAAV products at CMOs.
  2. Lead the internal team producing rAAV and coordinate production activities with research, non-clinical development, QA, QC, and clinical development.
  3. Ensure the ongoing security of the supply chain for raw materials and intermediates to ensure uninterrupted performance of rAAV operations.
  4. Coordinate the transfer, qualification, and implementation of process improvements and scale-up.
  5. Lead the reporting, investigation, and resolution of deviations encountered during GMP production activities.
  6. Participate in the design, construction, and commissioning of company manufacturing facilities.
Requirements

The ideal candidate for this position will have in-depth experience in the large-scale cGMP production of rAAV, including upstream cell culture, downstream processing, and fill finish operations. The candidate must possess a Master's or Ph.D. in bioprocessing, chemical engineering, vector biology, or biological sciences, with a minimum of 10 years of experience in the biotechnology or pharma industry.

The candidate should have a proven track record of managing in-house and CMO GMP production operations, with in-depth experience in mammalian cell, insect cell, and microbial cell culture systems at both pilot-scale and large-scale. Additionally, the candidate should have knowledge of FDA, EMA, GMP, and ICH regulatory requirements, as well as Quality Systems and QBD as they relate to GMP production operations and process optimization.

What We Offer

Sangamo Therapeutics offers a competitive base salary and the opportunity to participate in incentive compensation programs, including bonus and stock option plans. We also offer a comprehensive benefits program, including medical, dental, and vision care, paid vacation and holiday time, and access to a voluntary 401(k) and Employee Stock Purchase Plan.


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