Senior Staff Engineer, Modeling

3 weeks ago

Lexington, Kentucky, United States Takeda Pharmaceutical Company Ltd Full time

About the Role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients worldwide.

We are seeking a Senior Staff Engineer, Modeling to join our Advanced Technologies Group within Biologics Process and Product Development.

This role will focus on process development and optimization of production processes for biopharmaceuticals through modeling approaches for use in manufacturing facilities.

The successful candidate will have hands-on experience in process modeling applications and a strong background in biochemical engineering or biotechnology.

Key Responsibilities:

  • Mechanistic modeling of upstream and downstream processes with simulation software applications to enhance model-based process development.
  • Modeling of process sustainability and economics of new or improved biopharmaceutical manufacturing platforms and fit into manufacturing facilities.
  • Perform multivariate process trending analysis to support development and optimization of manufacturing processes for biopharmaceuticals and bioconjugates.
  • Model impact of innovative strategies on existing and new manufacturing processes.
  • Apply modeling approaches to process development including model transfer learning.
  • Provide modeling support for biopharmaceutical process characterization activities in preparation for process validation.
  • Evaluate process and cost modeling software applications for use in biopharmaceutical development.
  • Collaboration with internal and external groups.
  • Represent the Process Development Department on various project teams.
  • Develop AI/ML model applications for hybrid models, and the exploration of innovative approaches to model building, including AI/ML techniques.

Requirements:

  • Ph.D. degree or a M.S. degree in biochemical engineering/biotechnology or closely related fields with 3+ years (PhD.) or 9+ years (M.S.) of experience in modeling and bioprocess development.
  • Hands-on experience in process modeling applications (such as gProms, GoSilico, BioSolve, SIMCA, etc.).
  • Additional hands-on and lab-based process and/or high-throughput development experience is preferred.
  • Familiarity with cGMPs for biopharmaceuticals and regulatory submissions.
  • Ability to work well independently as well as a member of a team.
  • High communication skills, excellent written and verbal communication.
  • Programming skills (e.g. Matlab, Python).
  • Ability to present findings clearly to non-technical stakeholders.
  • Ability to work in fast-paced environments.
  • Teamwork skills for working in a diverse, global environment.
  • Willingness to stay updated with the latest industry trends and technologies.

About Takeda:

Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do.

We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

This position is currently classified as 'hybrid' in accordance with Takeda's Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career.

We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

The estimated salary range reflects an anticipated range for this position.

The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.

The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-term incentives.

U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.

U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

  • Senior Systems Engineer

    4 weeks ago

    Lexington, Kentucky, United States MIT Lincoln Laboratory Full time

    Job Title: Senior Systems EngineerThe Systems Engineering group at MIT Lincoln Laboratory is responsible for building one-of-a-kind prototypes to meet critical national security needs. Our team designs and develops complex systems, including satellites, space and airborne payloads, and laser communications and laser radar systems.Key Responsibilities:Develop...

  • Senior Mining Engineer

    4 weeks ago

    Lexington, Kentucky, United States RESPEC Inc. Full time

    h3Job Summary/h3pWe are seeking a highly skilled Senior Mining Engineer to lead our mining operations team. The ideal candidate will have a strong background in mining engineering and project management, with a proven track record of delivering successful projects./ppThe Senior Mining Engineer will be responsible for managing all aspects of mining...

  • Senior Machine Learning Engineer

    3 weeks ago

    Lexington, Kentucky, United States Xometry Full time

    About the RoleXometry is seeking a highly skilled Senior Machine Learning Engineer to join our team. As a key member of our organization, you will play a crucial role in advancing our machine learning capabilities and driving business growth.Key Responsibilities:Explore new machine learning opportunities and develop innovative solutions to improve Xometry's...

  • Senior Autonomous Systems Developer-Technical Staff

    3 weeks ago

    Lexington, Kentucky, United States MIT Lincoln Laboratory Full time

    Job SummaryThe Advanced Capabilities and Systems Group at MIT Lincoln Laboratory is seeking a senior autonomous systems developer to design, build, and test state-of-the-art autonomous systems as part of an agile, cross-functional team.ResponsibilitiesConcept development, modeling & simulation, feasibility assessment, system design, system...

  • Senior Machine Learning Engineer

    4 weeks ago

    Lexington, Kentucky, United States Xometry Full time

    Xometry is seeking a Senior Machine Learning Engineer to join our team. As a key member of our engineering organization, you will play a crucial role in developing and implementing machine learning models that improve our ability to predict cost, price, and sourcing options for our customers and suppliers.You will lead the evaluation of emerging...

  • Senior Mining Engineer

    4 weeks ago

    Lexington, Kentucky, United States RESPEC Inc. Full time

    At RESPEC, we are seeking a highly skilled Senior Mining Engineer to lead our mining operations team. The ideal candidate will have a strong background in mining engineering and project management, with a proven track record of delivering successful projects on time and within budget.The Senior Mining Engineer will be responsible for managing all aspects of...

  • Senior Mechanical Engineer

    3 weeks ago

    Lexington, Kentucky, United States KFI Engineers Full time

    Job SummaryAs a Senior Mechanical Engineer at KFI Engineers, you will play a key role in the successful execution of projects. Reporting to a Senior Project Manager, you will provide technical and engineering excellence, as well as successful delivery of work to our customers.Key Responsibilities• Prepares engineering documents and equipment specifications...

  • Structural Revit BIM Modeler

    4 weeks ago

    Lexington, Kentucky, United States GRW Engineers, Inc. Full time

    Job DescriptionGRW Engineers, Inc. is seeking an experienced Structural Revit BIM Modeler / CADD Technician to join our Lexington, KY headquarters.This position involves assisting project managers and engineers with the modeling and drafting of code specific and structurally sound designs of commercial, heavy industrial, institutional, and water and...

  • Senior Electrical Engineer

    3 weeks ago

    Lexington, Kentucky, United States CMTA Inc Full time

    About the Role:CMTA Inc is seeking a highly skilled Senior Electrical Engineer to join our team. As a Senior Electrical Engineer, you will be responsible for designing and overseeing the electrical systems, power distribution, lighting and lighting controls, emergency power, UPS, renewable energy systems, fire alarm system, low-voltage systems/coordination...

  • Senior Water Resources Engineer

    4 weeks ago

    Lexington, Kentucky, United States GRW Engineers, Inc. Full time

    Job DescriptionGRW Engineers, Inc. is seeking a Senior Water Resources Engineer to join our Lexington office and contribute to the growth of our water resource engineering team. As a key member of our team, you will be responsible for planning, designing, and constructing utility infrastructure projects. Your expertise in water resource engineering will be...

  • Senior Engineering Manager

    3 weeks ago

    Lexington, Kentucky, United States City of Louisville, KY Full time

    Job SummaryWe are seeking a highly skilled Senior Engineering Manager to oversee the engineering function of design, construction, testing, and implementation of construction projects. The ideal candidate will have a strong background in engineering and project management, with excellent communication and leadership skills.Key Responsibilities:Reviews and...

  • Senior Design Engineer

    3 weeks ago

    Lexington, Kentucky, United States Link-Belt Full time

    Link-Belt is seeking a highly skilled Senior Design Engineer to join our team. The ideal candidate will have a strong background in mechanical engineering and experience in the design and testing of new and existing products.The Senior Design Engineer will be responsible for designing and testing new and existing products, as well as assisting with the...

  • Senior Transmission Planning Engineer

    3 weeks ago

    Lexington, Kentucky, United States Jobot Full time

    Job OverviewOur client, a leading Utilities company, is seeking a highly skilled Senior Engineer to lead and oversee transmission system projects. As a Senior Engineer in Transmission Planning, you will play a vital role in our dynamic finance industry.Key ResponsibilitiesDevelop and maintain long-range transmission plans to ensure system reliability and...

  • Construction Materials Senior Engineer

    1 month ago

    Lexington, Kentucky, United States S&ME, Inc. Full time

    About the RoleWe are seeking a highly skilled Senior Engineer to join our construction engineering team in Lexington, KY. As a Construction Materials Senior Engineer, you will serve as a senior engineer for medium to large Construction Materials Testing and Special Inspections projects, ensuring the highest level of quality and compliance with industry...

  • Senior Network Engineer

    4 weeks ago

    Lexington, Kentucky, United States Windstream Full time

    Job SummaryWindstream is seeking a highly skilled Senior Network Engineer to join our team. As a key member of our Outside Plant Engineering group, you will be responsible for designing and developing complex solutions for network construction. Your expertise in telecommunications and network engineering will enable you to analyze and solve complex problems...

  • Senior Construction Materials Engineer

    4 weeks ago

    Lexington, Kentucky, United States S&ME, Inc. Full time

    About the RoleWe are seeking a highly skilled Senior Construction Materials Engineer to join our team in Lexington, KY. As a key member of our construction engineering team, you will be responsible for managing medium to large Construction Materials Testing and Special Inspections projects, ensuring the highest level of quality and compliance with industry...

  • Senior Reliability Engineer

    4 weeks ago

    Lexington, Kentucky, United States BioSpace, Inc. Full time

    About the RoleWe are seeking a highly skilled Senior Reliability Engineer to join our team. As a key member of our reliability engineering group, you will be responsible for improving the reliability of our equipment, utilities, and critical systems.Key ResponsibilitiesDevelop and implement maintenance strategies, plans, and SOPs for new and modified...

  • Air Modeling Specialist

    1 month ago

    Lexington, Kentucky, United States Tetra Tech Full time

    About the Role:Tetra Tech is seeking a highly skilled Air Modeling Specialist to join our team. As a key member of our High Performance Buildings Division, you will be responsible for defining and performing project tasks in a cost-effective and time-efficient manner.Key Responsibilities:Perform technical writing and presentations about regulatory concepts,...

  • Senior Systems Engineer

    4 weeks ago

    Lexington, Kentucky, United States Lockheed Martin Full time

    Job Summary:Lockheed Martin Missiles & Fire Control (MFC) is seeking an experienced Senior Systems Engineer to join our team in Lexington, KY. As a key member of our Systems Engineering team, you will be responsible for implementing the design lifecycle, including interface development, requirements flowdown, system-level integration, architecture...

  • Senior Mechanical Engineer

    3 weeks ago

    Lexington, Kentucky, United States Gray Architects & Engineers, LLC Full time

    Job SummaryThe Senior Mechanical Engineer - MEP is responsible for leading cross-disciplinary design teams working on HVAC and plumbing projects. In addition to project management responsibilities, the Senior Engineer will contribute to the design team based on expertise and experience in design.This individual will coordinate all design activities of the...