Radiopharmaceutical Modeling Expert

6 days ago


Cambridge, Massachusetts, United States Novartis Group Companies Full time
About the Role

We are seeking a talented Radiopharmaceutical Modeling Expert to accelerate radioligand discovery and development by facilitating rigorous decision-making with modeling and simulation.

This role will involve working in a multi-disciplinary environment, engaging in cross-functional initiatives, and collaborating with colleagues from various backgrounds.

Key Responsibilities:
  • Develop and execute modeling strategies for radioligand therapy programs, contributing to project team discussions, and guiding therapeutic design and dose selection decisions.
  • Become proficient in building innovative QSP and physiologically based PK (PBPK) models along with dosimetry estimations to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
  • Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups.
  • Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
  • Seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
Requirements:
  • A Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field, along with demonstrated expertise in radiobiology/nuclear medicine. At least 2-3 years of related experience ideally in industry is required for consideration at the Principal Scientist II level.
  • Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred.
  • Expert-level proficiency in core modeling fundamentals, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
  • The ability to communicate modeling results effectively to a multidisciplinary audience to facilitate decision-making.
  • Leadership experience and ability to coach/mentor junior modelers are desired for consideration at the Principal Scientist II level.
  • Fluency in English (oral and written).
Compensation and Benefits:

The estimated salary for this position is between $130,400 and $195,600 per year, depending on experience, skills, and qualifications.

Novartis offers a comprehensive benefits package, including medical, financial, and time-off benefits, which will be discussed further if an employee receives an offer of employment.



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