Senior Vaccine Research Scientist, Immunoassay Development

2 days ago


San Mateo, California, United States Vaxcyte Inc Full time

Company Overview

Vaxcyte Inc. is a cutting-edge vaccine company that aims to revolutionize global health by developing innovative and effective vaccines against infectious diseases. Our proprietary platform and expertise enable us to design and produce optimized protein carriers and antigens, which we believe are critical for creating superior vaccines.

We have a strong pipeline of vaccine candidates, including pneumococcal conjugate vaccines (PCVs) that target the $7 billion global PCV market. Our lead candidate, VAX-24, has demonstrated potential to replace the standard of care and is expected to advance into clinical trials soon.

Job Description

We are seeking an experienced and skilled Senior Vaccine Research Scientist to join our Immunoassay team. The successful candidate will play a key role in supporting developmental activities in our laboratory, focusing on the management and execution of key stability indicating assays, primarily the bioassay. This assay uses MSD as the analytical measurement tool and will be used to assess both drug substance (DS) and drug product (DP) concentration and stability.

The final product is an adjuvanted vaccine with antigens bound to solid aluminum particles. Part of the complexity lies in developing a system to effectively remove the antigens from this surface prior to analysis. Matrix effects and stability of the product throughout this process must also be assessed. Given the multiple serotypes of this antigen within the drug product, a separate assay needs to be developed and optimized for each serotype. Ultimately, all assays for DS and DP analysis must be pre-validated prior to transfer to a Contract Manufacturing Organization (CMO). Assistance in developing further MSD/ELISA based immunoassays for phase 3 and research pipeline programs will also be required.

This position offers a unique opportunity for the right candidate to make a significant impact on the product and the company. The ideal candidate should have extensive monoclonal based immunoassay experience, preferably in development, optimization, and pre-validation/validation of said assays. Prior MSD/ELISA experience and vaccine development background where the system contained aluminum or other adjuvants are highly desirable.

Required Skills and Qualifications

  • Bachelor's or Master's degree in Chemistry or Analytical Chemistry preferred; Organic / Biochemistry considered with >3 years of industrial experience or PhD with >1 year
  • Experience working with MS-based analytical tools and ELISA assays
  • Understanding of vaccine development, particularly adjuvanted systems and multiple serotype challenges
  • Strong scientific judgment and ability to work independently
  • Excellent communication and interpersonal skills
  • Ability to work under supervision in a fast-paced, cross-functional environment and collaborate effectively with other team members

Benefits and Salary Information

We offer a competitive compensation package, including comprehensive benefits and an equity component. The estimated salary range for this position is $120,000 - $150,000 per annum, depending on experience and qualifications.



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