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Senior Research Laboratory Specialist
2 months ago
Job Summary:
An exciting opportunity has been created for an experienced researcher to join the Alumkal Laboratory at the University of Michigan Division of Heme-Onc and the Rogel Cancer Center in Ann Arbor, MI. The individual will join as a Research Lab Specialist Senior and work directly with Dr. Joshi Alumkal, Leader of the U of M Progenitor/Genitourinary Oncology Cancer Section. They will be an integral member of a research team whose focus is epigenetics and drug resistance in prostate cancer.
Our Goal:
Our goal is to develop new, targeted treatment strategies for men with advanced prostate cancer. Our laboratory focuses on identifying mechanisms by which key chromatin modifying enzymes and chromatin readers drive transcription of pathways that promote treatment resistance. We use genomics studies in prostate cancer clinical samples and genomic and functional studies in prostate cancer in vitro and in vivo model systems to understand this process.
Responsibilities:
- Performing laboratory experiments - Independently and collaboratively develop and manage research experiments, determining the most suitable methods to be used. Interpret and perform complex data analysis on experimental results and determine whether they are consistent with goals.
- Project management: Develop and oversee laboratory research projects in collaboration with PI. Provide direction and ideas including identification of scientific problem, design of approach to address it, and identification, acquisition, and management of resources to perform investigations.
- Grant preparation and financial laboratory management: In collaboration the PI, help prepare grant applications, including planning, budgeting, editing, and figure preparation. Attend budget meetings and participate in resource allocation and planning, including assigning personnel effort to specific grants and projects.
- Prepare manuscripts for publication including writing, editing, figure preparation, revisions, and submission in collaboration with project leaders (i.e. Research Fellows, Clinical Fellows, Staff Scientists).
- Track personnel progress on their projects and help ensure maximum productivity. Foster and support teamwork. Ensure that research team members maintain accurate and detailed records of all experimental procedures, data collections and analysis performed.
- Provide training to all members of the lab including staff scientists, postdoctoral fellows, clinical research fellows, graduate students, and undergraduate students.
Requirements:
- Master's Degree required
- 5-6 years related experience
- Supervisor and financial management experience required
- Molecular biology techniques required: PCR, primer design, cell culture, transfections, transductions, Western blots, cloning.
- Ability to generate figures, assist in manuscript and grant submissions, and provide scientific and writing feedback.
- Familiarity with supply ordering, procurement, and lab management.
- Strong publication record.
- Proven ability to work collaboratively with and manage a high performing laboratory group.
- Proficient with computers specifically MS Office (which includes Excel, Word, and PowerPoint), Adobe Illustrator, Adobe Photoshop, and statistical analysis software such as GraphPad Prism.
- Knowledge of policy and regulations applicable to the laboratory, including but not limited to safety, animal work, and radiation.
- Technical proficiency, scientific creativity collaborative ability, and independent thinker.
- Must have excellent communication, analytical and organizational skills: both written and verbal.
- Ability to work independently and as part of a team while being collaborative in resolving problems.
- Must possess energy and drive to coordinate multiple projects simultaneously, including those led by other team members.
- Ability to use tact and diplomacy to maintain effective working relationships.
- Ability to operate complex scientific equipment and develop and troubleshoot complex experimental protocols.
- Demonstrated ability to build productive cross functional collaborations both internally and externally.
- Ability to analyze short- and long-term project needs. Ability to strategize long term laboratory-wide research directions.
- Ability to schedule, manage and coordinate multiple projects and priorities simultaneously.
Preferred Qualifications:
- Doctoral degree in relevant field and 3 years of relevant post-doctoral work experience.
- Expertise in epigenetics, genomics, and cancer biology are required. Expertise with ChIPseq, RNAseq, RRBS, scRNAseq, and data visualization/analysis is strongly preferred. Experience with CRISPR/Cas9 KO technology is strongly preferred.
Why Work at the University of Michigan?
The University of Michigan is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits Can You Look Forward to?
Excellent medical, dental and vision coverage effective on your very first day. 2:1 Match on retirement savings.
