Senior Scientist

1 week ago


CT United States Pfizer Full time
Why Patients Need You

Pfizer's mission is to deliver breakthroughs that transform patients' lives. Our Research and Development team is at the forefront of this mission, working to translate advanced science and technologies into innovative therapies and vaccines that make a meaningful difference. As a member of our team, you will apply cutting-edge design and process development capabilities to accelerate the development of best-in-class medicines and bring them to patients around the world.

What You Will Achieve

As a key member of our Pharmaceutical Sciences function, you will support Pfizer's early to late-stage portfolio by translating new chemical entities into commercial drug products. You will work in a collaborative team that integrates Chemistry and Manufacturing and Controls capabilities, encompassing state-of-the-art active pharmaceutical ingredient synthesis and drug product design, as well as cGMP manufacturing and clinical trials supply chain.

As a Computational Materials Scientist, You Will
  • Apply state-of-the-art computational chemistry and crystallographic tools to predict the solid-state and particle properties of Pfizer molecules, streamlining experimental efforts and designing better medicines.
  • Conduct crystal structure prediction (CSP) calculations and free energy calculations for polymorph stability ranking.
  • Utilize various physics/informatics-based computational tools for design and derisking of commercial solid form.
  • Develop and apply physics/ML-AI-based computational tools to investigate and understand the particle properties, surface, and performance.
  • Participate on multidisciplinary project teams and collaborate with colleagues to define and recommend follow-up screening and characterization strategies to complement computational studies according to project timelines.
  • Oversee the work of external partners conducting computational analyses and provide tactical guidance and critical analysis of their work.
  • Solve scientific problems using contemporary solid-state computational techniques.
  • Lead the development of new scientific approaches and knowledge within the Material Sciences organization.
Qualifications

To be successful in this role, you will need:

  • A PhD in Computational Chemistry, Physics, Materials Science, or Engineering, or a Master's degree in these disciplines with 5-10 years of relevant experience in industry or academia.
  • Strong coding skills in a scientific programming language (such as C/C++, Python, Perl) with demonstrated evidence of coding expertise and data analysis.
  • Competency in UNIX/Linux and HPC environments for submission and monitoring of jobs.
Preferred Qualifications

While not required, experience with computational chemistry software (GROMACS, Gaussian, GAMESS-US, cp2k, quantum espresso, and VASP) and the CCDC tools is preferred. Knowledge of fundamental physical chemistry and materials science concepts, such as thermodynamics, solvation, crystallography, symmetry, nucleation, and crystal growth, is also desirable.

Relocation Support Available

Pfizer offers relocation support to help you and your family make a smooth transition to our location.

This role is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and support each of life's moments. Benefits include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday, and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental, and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.


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