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Senior Computational Chemist
2 months ago
Gate Bioscience, Inc. is a pioneering biotech company dedicated to revolutionizing the field of medicine with its innovative Molecular Gates technology. Our mission is to develop a new class of medicines that selectively eliminate harmful extracellular proteins, thereby curing diseases at their origin.
The Role:
We are seeking an exceptional Computational Chemist to play a key role in developing optimization strategies for our most critical drug discovery campaigns. This highly skilled professional will review experimental results, develop SAR hypotheses for activity, selectivity, and properties, and provide suggestions to improve the profiles of our leading molecules.
Key Responsibilities:
- Spearhead modeling initiatives and strategically apply computational chemistry expertise across all stages of a program, including target selection, target validation, lead generation, and lead optimization.
- Utilize various informatics and modeling techniques to analyze large datasets and accelerate the evolution of drug discovery leads, as well as enhance our chemical library.
- Identify gaps in current methodologies, implement new technologies, and lead the internalization of promising approaches.
- Lead aspects of our capability build and working groups toward our future-state vision of computational drug discovery at Gate Bioscience, Inc.
- Be curious, innovation-driven, and willing to test out hypotheses and embark on novel method development.
- Effectively communicate with colleagues and stakeholders, create and present research updates, and provide strategic input to team/company meetings.
What You'll Achieve:
In the first month, you will work closely with our scientists to gain understanding of internal drug discovery and pre-clinical programs and begin to define best practices from a computational perspective.
By three months, you will begin to review experimental results and analyze datasets to build expertise as you develop modeling initiatives geared toward chemical diversity expansion and mechanism of action.
By six months, you will begin to provide suggestions on how to improve the profiles of our leading projects and to provide insights into the molecular mechanism of action.
Requirements:
- Ph.D. or M.S. in a computational chemistry or related discipline.
- 8+ years of experience in the pharmaceutical/biotech industry.
- Expert-level experience with a wide range of leading computational tools and approaches, including prediction/model development with application across all stages of a project from hit ID through to candidate nomination.
- Evidence of creative application of computational chemistry approaches to problems of biological interest.
- Demonstrated broad success in advancing drug discovery through computation, both independently and as a team leader.
- Strong oral and written communication skills, with a recognized ability to positively influence decisions and strategy.
- Defining best practices for computational chemistry and directly influencing their execution.
Compensation:
Gate Bioscience, Inc. offers a competitive salary range for this position, with individual compensation based on various factors, including level, experience, education, skill set, and geographic location. This range is for our San Francisco Bay Area location and may be adjusted to the labor market in other geographic areas. Target Salary Range: $170,000 - $270,000.
In addition to salary, Gate Bioscience, Inc. offers equity in the company, a robust benefits package, 401(k) program with employer match, and the opportunity to be a part of groundbreaking research.
Gate Bioscience, Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, or gender identity, national origin, disability, or veteran status.
