Biological Therapeutics Development Expert

6 days ago


Branford, Connecticut, United States EVOLVEIMMUNE THERAPEUTICS INC Full time

Company Overview:

EvolveImmune Therapeutics Inc. is a pioneering company in the field of immune-oncology, committed to developing novel trispecific T cell engagers with integrated CD2 costimulation for effective cancer treatment.

Job Description:

We are seeking an experienced Senior Scientist to join our Biotherapeutics group and contribute to the development of next-generation immunotherapies. As a key member of our team, you will be responsible for engineering novel drug candidates utilizing our co-stimulatory EVOLVE platform and collaborating with other functions in research and development to advance candidate molecules through preclinical research.

The successful candidate will have substantial industry experience in protein biochemistry, protein/antibody expression and purification from mammalian cells using state-of-the-art chromatography systems. They will also possess expertise in protein and vector engineering, protein expression/purification, and biophysical characterization. Additional responsibilities may include tissue culture and cell biology work as well as cell-based assays, flow cytometry, PCR/qPCR, and cell line engineering.

Responsibilities:

  • Purify proteins and antibodies from mammalian cells using affinity, size exclusion, and ion exchange chromatography.
  • Engineer monoclonal and bispecific antibodies and construct expression vectors.
  • Support biophysical characterization of proteins and antibodies using advanced technologies for binding kinetics and biophysical properties.
  • Collaborate with other teams to establish biophysical and cell-based assays for antibody characterization and prioritization towards lead selection.
  • Mentor junior members of the Biotherapeutics group and contribute to building a culture that embraces scientific excellence and continuous learning.

Qualifications and Experience:

  • PhD in Molecular Biology/Biochemistry/Cancer Biology or related discipline with at least 1-3 years industry experience; or MS in Molecular Biology/Cancer Biology/Biochemistry or related discipline with 5+ years of industry experience.
  • Extensive hands-on experience with protein expression in mammalian systems (HEK, CHO, transients, and stable pools) and purification by various chromatographic methods.
  • Experience with biochemical and biophysical characterization of biologics, including ELISA, BLI/SPR, and SE-HPLC.
  • Ability to learn new techniques quickly and follow established protocols with precision.
  • Strong interpersonal skills and ability to work in a team-based environment.

Estimated Salary: $120,000 - $160,000 per year, based on location and experience.



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