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Senior Principal Scientist, Process Chemistry
4 weeks ago
We are seeking a highly skilled Senior Principal Scientist, Process Chemistry to join our team at Phlow Corp. The successful candidate will possess a strong background in process chemistry and API manufacturing, with a proven track record of delivering high-quality results in a fast-paced environment.
Key Responsibilities- Provide process chemistry support to Phlow's Advanced Manufacturing R&D lab to ensure project deliverables are met on time and on budget.
- Design, synthesize, purify, and analyze chemical intermediates, target compounds, and impurities.
- Maintain accurate, legible, and complete records of all experiments and observations.
- Author progress reports and present scientific results to team members.
- Exhibit a high level of safety awareness and conduct lab operations in a safe manner.
- Contribute to the timely and accurate preparation of regulatory submissions.
- Participate in the ongoing continuous improvements in manufacturing processes resulting in improving product quality, robustness, and cost.
- Collaborate with Analytical Chemistry, EH&S, Engineering, Project Management, Quality Assurance and Regulatory Affairs to ensure strong working relationships with all partners and Phlow employees.
- Minimum of 5 years working in related roles in the pharmaceutical industry.
- A broad range of functional expertise in modern synthetic organic chemistry, compound purification, spectral analysis/interpretation.
- Experience with searching the chemical literature to evaluate potential solutions to synthetic problems.
- Experience with common analytical techniques such as: HPLC, GC, NMR, UV, LC-MS.
- Strong interpersonal and communication skills.
- Ph.D. with a minimum 5 years of experience, M.S with a minimum 10 years of experience, or B.S. degree with a minimum 15 years of experience in Organic Chemistry, Pharmaceutical Sciences, or a related scientific field.
- Process chemistry and API manufacturing experience on multi-kilogram scale.
- Knowledge of ICH and cGMP requirements.
- Experience working for a contract organization (CROs/CMOs/CDMOs).
- Experience with technical and operational risk assessments (e.g., process robustness, mutagenic impurities, nitrosamines, etc.).
- Experience with the development and implementation of continuous flow manufacturing processes.
