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Senior Research Scientist

2 months ago


San Francisco, California, United States city of San Elizario Full time
About the Role

We are seeking a highly skilled and experienced Senior Scientist to join our Inflammation Research team in San Elizario. As a key member of our team, you will be responsible for designing and executing experiments to explore and understand the pharmacology of drug targets, generating and communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists.

Key Responsibilities
  1. Experiment Design and Execution: Oversee the design, execution, and data analysis of cutting-edge research and in vivo pharmacology experiments contributing to Amgen's Inflammation TA research pipeline.
  2. Pharmacology and Animal Models: Utilize in vivo pharmacology and animal models to validate and accelerate molecules through the research pipeline.
  3. Collaboration and Communication: Inform, collaborate, and communicate in vivo strategy with therapeutic area (TA) scientists to align with project goals.
  4. Data Quality and Analysis: Oversight of study data quality and analysis from group.
  5. Presentations and Reporting: Present results at internal meetings and external conferences.
Requirements

We are looking for a highly motivated and experienced scientist with a strong background in Immunology, Inflammation, Autoimmune Disease, or related disciplines. The ideal candidate will have a Doctorate degree (PhD, PharmD, or MD) and relevant post-doc experience, or a Master's degree with 3 years of experience, or a Bachelor's degree with 5 years of experience.

Preferred Qualifications
  1. Post-Doctoral Training: PhD degree and post-doctoral training (or drug discovery experience) in the fields of Immunology, Inflammation, Autoimmune Disease, or related disciplines.
  2. Research Experience: Significant hands-on expertise in animal (mouse and rat) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) preferred.
  3. Model Development: Experience designing and executing in vivo preclinical inflammation and autoimmune disease models. Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA) models preferred.
  4. Technical Skills: Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi-color flow cytometry, quantitative RT-PCR) preferred.
  5. Computer Literacy: Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint, and Word.
  6. Communication Skills: Excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.
  7. Leadership Skills: Demonstrated track record of independent critical thinking and scientific achievement.
  8. Teamwork: Ability to work in a flexible team-oriented environment.