Senior mRNA Delivery Expert, LNP Innovation and Engineering
6 days ago
Company Overview
Strand Therapeutics is a clinical-stage biotechnology company that utilizes synthetic biology to develop revolutionary immunotherapies. The company was founded by biological engineers who applied the concept of Boolean logic circuits to create smart therapies based on mRNA.
The technology developed at Strand is therapeutic-area and mRNA modality agnostic. It involves encoding therapeutic proteins onto modified, self-replicating, or circular mRNA backbones programmed with cell-specific sensors and circuits. This approach has led to the establishment of three platforms, one of which is in a phase 1 clinical trial for solid tumors.
The company's headquarters is located in Boston, Massachusetts, and it offers a fast-paced, entrepreneurial environment that supports professional development while working together to meet its goals.
Job Description
We are seeking a highly motivated and innovative candidate to join our team as a Senior mRNA Delivery Expert, LNP Innovation and Engineering. The ideal candidate will have experience in the formulation and characterization of LNPs and contribute to advancing Strand's mRNA delivery platform and capabilities.
Primary Responsibilities
- Contribute to LNP innovation, engineering, and process screening to support pipeline programs.
- Characterize the physiochemical properties of LNPs and components using standard or newly developed in-house assays.
- Evaluate the delivery capability of LNPs using standard or newly developed cell-based assays.
- Execute LNP composition optimization and screening assays.
- Compile data reports and communicate the results with relevant teams.
- Produce LNP formulations to support internal and partnered programs.
Required Skills and Qualifications
- Bachelor's degree in Pharmaceutical Sciences, Biomedical Engineering, Chemical Engineering, or other relevant scientific discipline.
- 5-6+ years of experience with a focus on discovery & development of LNP formulations with nucleic acid-based payloads required.
- Experience with production and analytical characterization of mRNA LNPs (DLS measurement, RiboGreen assay, luciferase assay etc.).
- Mammalian cell culture and cell-based assays experience is highly preferred.
- Familiarity with high-throughput screening of mRNA LNPs would be a plus.
Benefits
Strand Therapeutics offers a top-notch benefits package, including health, dental, life insurance, open PTO, onsite lunch catering, commuter support, and more. We also provide a fast-paced, entrepreneurial environment that supports professional development while working together to meet our goals.
Estimated Salary: $120,000 - $150,000 per year, commensurate with role and experience.
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