Process Engineering Associate Fellow

3 weeks ago


Boston, United States Takeda Pharmaceutical Company Ltd Full time

Synthetic Molecule Process Development (SMPD) is seeking an experienced Process Engineering Associate Fellow for the development of robust, sustainable, and cost-effective processes for the manufacture of new synthetic molecule pharmaceutical. In this role, you will contribute to multiple projects, mentor junior engineers and use your technical expertise to drive technical/scientific strategy. You will be responsible for all aspects of reaction & particle engineering, including the development of scale down models for the study of unit operations, process safety evaluation, and technical transfer to external contract manufacturing organisations. You will collaborate closely with the Chemistry and Technology groups to apply enabling & emerging development and manufacturing technologies and will be responsible for helping shape the department's technology roadmap, based on pipeline needs and current trends in research.

  • Develop project and technical strategy
  • Collaborate with cross-functional teams to develop effective process engineering strategies
  • Drive process optimization initiatives to improve sustainability, process efficiency, yield, quality, and cost-effectiveness
  • Oversee process scale-up activities from laboratory to pilot plant and commercial-scale production
  • Conduct analysis of technical and conceptual risk through robust process characterization, failure mode analysis, and risk assessment methodologies, identifies trends and defines and champions process or scientific strategies
  • Coordinate and lead technology transfer to internal or external manufacturing sites or vendors

Minimum Requirements/Qualifications:

  • A Ph.D. degree with 7+ years of pharmaceutical industry experience; an MS degree with 13+ years of pharmaceutical industry experience; or a BS degree with 15+ years of pharmaceutical industry experience. Degrees in chemical engineering required
  • Extensive experience in the use of mathematical, both statistical and first principle, models as well as advanced process control systems preferred
  • Experience in crystallization process development and scale-up preferred
  • Experience in the use and scale-up of milling technologies (both dry and wet) for particle size control preferred
  • Experience in the use of process analytical technologies required
  • Experience in developing continuous processes a plus


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