Principal Data Scientist, Real World Evidence

3 weeks ago

New York, United States RECURSION CO Full time
Your work will change lives. Including your own.

The Impact You'll Make

We are seeking a Principal Data Scientist to support clinical trial planning and to contextualize observed efficacy of experimental arms in trials against other active agents not studied within the trial, via non-randomized comparisons using external data sources.

At the study planning stage, you will leverage various business intelligence data - sourced from historical trials and real-world data - to support enrollment modeling, powering assumptions, biomarker-enrichment, and other study planning needs. The intent is to optimize trial design with data-driven insights.

During a trial, or shortly after conclusion of a trial, you will leverage external data sources to contextualize the observed efficacy of the experimental arm. These insights will be generated via meta-analyses, externally controlled designs using real-world data or trial data, and other sources. The intent is to inform decision making during early development.

To be successful, you will be required to have a minimum of 5 years of experience working within the life sciences industry. A strong foundation in statistical modeling, causal inference, and statistical programming, as well as experience in oncology real-world data linked with genomic sequencing information.

In this role, you will:
  • Data Integration & Analytics: Leverage diverse data sources, including insurance claims, EHRs, omics data, and other real-world datasets, to generate actionable insights to support drug development
  • Enrollment Modeling and Predictive Forecasting: Lead enrollment modeling efforts, applying Monte Carlo Simulations and other approaches to accurately estimate patient enrollment rates, model study timelines, and mitigate recruitment risks
  • Statistical Modeling: Regression modeling using patient-level and summary-level (i.e., meta-analysis) data. Propensity score models to correct for imbalances between trial-enrolled population and external data sources
    Statistical Programming: Manipulate data and effectively report the data
  • Collaboration & Cross-Functional Support: Work closely with colleagues in Inception Labs, Discovery, Translational Science, Clinical Operations, Clinical Development, Biostatistics, Regulatory teams, and external partners to apply insights to trial design, site selection, and patient recruitment strategies
    Data Visualization & Reporting: Develop clear and actionable reports using BI tools (e.g., Tableau, Power BI) to present insights, enrollment forecasts, and data-driven recommendations to senior leadership and key stakeholders
  • Data Quality & Management: Ensure high data quality by cleaning, organizing, and maintaining datasets from various sources, enabling robust analyses and reliable decision-making
The Team You'll Join

Reporting to the VP, Decision Science, you'll be joining a team that will help Recursion design optimal clinical trials and support portfolio level decision making. This is a new, small group that will have expertise in causal inference and its applications in observational, real-world data and historical trial data (at the patient-level and the summary level). This will be a fun, fast-paced work environment full of passionate colleagues who are integrating cutting edge technology into drug development. Inclusiveness, respect, scientific rigor, and strategic thinking are key behavioral attributes of the team.

The Experience You'll Need
  • Master's or PhD in Data Science, Biostatistics, Epidemiology, Bioinformatics, or related field with a minimum of 5 years of experience working with RWD in the pharmaceutical, biotech, or life sciences consultancy
  • Demonstrated expertise in analyzing insurance claims, EHRs, and genomic data for drug development insights
  • Expert skills in at least one statistical programming tool such as R, SAS, or other languages is a must. Expertise in SQL is also a must
  • Experience with BI tools such as Tableau, Power BI, or similar for data visualization and reporting
  • Strong understanding of data management platforms and clinical trial management systems
  • Excellent analytical and problem-solving skills, with experience in handling large and complex datasets
Working Location:

This position is based at our office located in New York City, NY. Please note that we are a hybrid environment and ask that employees spend 50% of their time per week in office.

#LI-LM1

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is:
  • Developing: $224,000
  • Skilled: $232,000
  • Expert: $249,000
To learn more about our level within levels, click here.

You will also be eligible for bonuses and equity compensation + our comprehensive benefits package for United States based candidates. The range displayed on each job posting reflects target ranges for US new hire salaries and is determined by job, level, and market factors.

During the interview selection process, you will connect with a Talent Acquisition Partner who will be your advocate and ally to ensure you receive the appropriate compensation that meets your needs for your skills, experience, and relevant education/training, while also reviewing our very competitive total rewards package.

The Values That We Hope You Share:
  • We Care: We care about our drug candidates, our Recursionauts, their families, each other, our communities, the patients we aim to serve and their loved ones. We also care about our work.
  • We Learn: Learning from the diverse perspectives of our fellow Recursionauts, and from failure, is an essential part of how we make progress.
  • We Deliver: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: we sprint at maximum engagement, making time and space to recover.
  • Act Boldly with Integrity: No company changes the world or reinvents an industry without being bold. It must be balanced; not by timidity, but by doing the right thing even when no one is looking.
  • We are One Recursion: We operate with a 'company first, team second' mentality. Our success comes from working as one interdisciplinary team.

Recursion spends time and energy connecting every aspect of work to these values. They aren't static, but regularly discussed and questioned because we make decisions rooted in those values in our day-to-day work. You can read more about our values and how we live them every day here.

More About Recursion

Recursion is a clinical stage TechBio company leading the space by decoding biology to industrialize drug discovery. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously expands one of the world's largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale - up to millions of wet lab experiments weekly - and massive computational scale - owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in London, Toronto, Montreal and the San Francisco Bay Area. Learn more at www.Recursion.com, or connect on X (formerly Twitter) and LinkedIn.
Recursion is an Equal Opportunity Employer that values diversity and inclusion. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation.
Recursion welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.

Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursion's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion, and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.

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