Associate Director, Bioinformatics

2 weeks ago


Watertown, United States Remix Therapeutics Full time

Remix launched with a vision to transform patient’s lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to patients. Remix has a commitment to demonstrate the highest levels of scientific integrity with urgency because those patients are counting on us to deliver. With an in-house technology platform built from scratch, we have rapidly generated multiple drug discovery programs that are advancing towards the clinic.

We seek a highly motivated, experienced translational bioinformatic leader to join our team located in Watertown, MA. As a translational bioinformatician reporting to the Head of bioinformatics and data science, this person will direct in collaboration with a cross-functional team of scientists and clinical experts the translational strategy and multi-omics analysis of complex data sets for the different projects leading to the development of novel RNA processing medicines. The ideal candidate will have a strong background in bioinformatics as well as translational expertise in one or more target areas relevant to Remix, especially oncology and/or neurodegeneration, and will be driven to succeed within a hypothesis-driven, team-oriented, and interdisciplinary biotech environment. The individual will be expected to contribute to all stages of drug development, supporting the translational efforts from the preclinical stage to marketing.

Principle duties and responsibilities:

Engage with the clinical and biomarker teams to organize and extract evidence of activity and other biological insights from emerging clinical data

Analyze complex multi-omics data sets across various modalities and connect insights and observations to clinical endpoints, highlighting possible indication expansion for key targets

Contribute to the translational computational strategy for a number of exciting early-and late-stage targets in the Remix portfolio, as well as partnered targets across diverse disease areas

Mine public and private multi-omic datasets including real-world data relating to Remix target areas for insights into patient stratification and biomarker strategies for early and late stage programs across Remix target areas, with a current focus on oncology and neurodegeneration

Work with internal groups at Remix as well as external partners to solve problems using cutting-edge data analysis and visualization

Participate and thrive in a culture of effective collaboration between experimental and computational scientists

Qualifications:

PhD in Computational Biology, Bioinformatics, or Computer Science, with 7+ years of total experience working in disease target areas relevant to Remix, especially oncology and/or neurodegeneration

Outstanding bioinformatics programming skills in at least one language relevant to data analysis such as Python or R

Ability to effectively communicate methodologies and results with colleagues, including bench scientists, research management, and project team leaders

Knowledge of RNA biology a plus, especially RNA splicing

Strong leadership skills

Strong problem-solving and troubleshooting skills

Ability to work in a dynamic and fast-paced environment independently and efficiently

Authorized to legally work in the US

Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation, or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Note to Third Party Staffing Agencies : Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.

#J-18808-Ljbffr



  • Watertown, United States Planet Pharma Full time

    Location: Waltham, MA - 3 days / week onsite Salary: AD - $175K + 20% bonus; Director - $200K+ 22% Bonus Top Skills Proven ability to lead Trial Master File (TMF) strategy, streamline processes, oversee vendor management, and ensure inspection readiness. Strong background in managing vendors effectively. Extensive experience with inspection readiness and...


  • Watertown, United States Wolters Kluwer N.V. Full time

    Partner with the Health HRVP and LOB team to establish, drive, and manage the Division talent agenda in alignment with the Wolters Kluwer talent strategy and priorities. Partner with the Analytics COE to analyze metrics and qualitative data to provid Director, Talent, Associate, Management, Business Partner, Support, Technology


  • Watertown, United States AstraZeneca, plc Full time

    Gaithersburg, MD or Waltham, MA - Join AstraZeneca, a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the worlds most serious disea Director, Evidence, Associate, Clinical, Healthcare, Data Scientist


  • Watertown, United States Tome Biosciences Full time

    At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story,...


  • Watertown, United States Affini-T Full time

    About Affini-T Therapeutics Affini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a "best-in-class" TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant diseases. Through the application of...


  • Watertown, United States Affini-T Full time

    Job DescriptionJob DescriptionAbout Affini-T Therapeutics Affini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a “best-in-class” TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant...


  • Watertown, United States Boston Dynamics Full time

    As Associate Director ML Platform on the Central Software team, you'll spearhead development and expansion of machine learning (ML) capabilities at Boston Dynamics. You'll oversee the design, implementation, and operations of infrastructure, and pipelines that unify how our many product ML/RL engineers and researchers get stuff done. If you are passionate...


  • Watertown, United States ESR Healthcare Full time

    Emergency Department Director Watertown WI 53098 Job Type :Direct Hours :Full Time Required Education :Associates Degree Travel :No Relocation :No Job Industry :Healthcare - Health Services Job Category :Healthcare - Other Job Description : Description POSITION SUMMARY The Director, Emergency/Trauma Service (Director), under the general direction of the...


  • Watertown, United States AgCareers.com Full time

    Company: Glacial Lakes Energy (GLE) The Director of Operations will oversee the production management in Glacial Lakes Energy (GLE) affiliated facilities. This role is responsible for identifying, developing and managing process improvement methodologies and facilitates the definition of new and/or improved operational processes within GLE to meet new...


  • Watertown, United States Alkermes Full time

    Job Description Outstanding opportunity for a strong training leader who possesses managed markets experience, knowledge of market access, fulfillment, and contracting processes and challenges, and an understanding of the managed care landscape. The candidate should demonstrate a passion for building and delivering development programs supporting all levels...


  • Watertown, United States Corner Therapeutics Full time

    The Senior Research Associate will report to the Director of Immunology in the Preclinical Department. Within the Preclinical Department, the predominant focus will be to generate data in support of bringing our innovative therapies to the clinic. Specifically, scientific work will focus on the use of primary cells and cell lines in tissue culture to...


  • Watertown, United States Corner Therapeutics Full time

    Job DescriptionJob DescriptionSalary: The Senior Research Associate will report to the Director of Immunology in the Preclinical Department. Within the Preclinical Department, the predominant focus will be to generate data in support of bringing our innovative therapies to the clinic. Specifically, scientific work will focus on the use of primary cells and...


  • Watertown, United States Affini-T Full time

    Job DescriptionJob DescriptionAbout Affini-T Therapeutics Affini-T Therapeutics is a biotechnology company focused on targeting oncogenic driver mutations with a “best-in-class” TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant diseases....


  • Watertown, United States Landmark Bio Full time

    Landmark Bio translates groundbreaking research into life-changing medicines. We provide development, manufacturing, and regulatory capabilities to help early-stage life science innovators rapidly progress advanced therapies from bench to clinic. Launched in 2021, and based in Watertown, Mass. Landmark Bio is an unprecedented venture bringing together the...


  • Watertown, United States Landmark Bio Full time

    You'll lead a dynamic cross-functional team in producing clinical supply products under cGMP conditions. Your responsibilities include ensuring safe, high-quality, and efficient product delivery while fostering employee development and engagement. You'll play a pivotal role in establishing and optimizing Viral Vector and Fill Finish Operations during the...


  • Watertown, United States Convergent Research Full time

    Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians. Why? Protein dysfunctions directly...


  • Watertown, United States Convergent Research Full time

    Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians. Why? Protein dysfunctions directly...


  • Watertown, United States NORTH COUNTRY FAMILY HEALTH CENTER Full time

    Position Summary: The Administrative and Human Resource (HR)/Compliance Coordinator provides direct executive support to the Chief Executive Officer & HR/Compliance Director. Responsible for assisting the HR/Compliance Director with implementing and adhering to the Health Center's Corporate Compliance Plan. Maintains the Health Center's Corporate Compliance...


  • Watertown, United States ElevateBio Full time

    ElevateBio is a technology-driven cell and gene therapy company, accelerating access to the cutting-edge technologies and expertise to change the future of medicine. Our integrated technologies model offers turnkey scale and biotechnological capabilities to power genetic medicines processes, programs, and companies to their full potential. The Role:...


  • Watertown, United States LCB Senior Living, LLC Full time

    Job DetailsJob Location The Residence at Watertown Square - Watertown, MA Position Type Full Time Description SUMMARY: Active member of the Resident Care Team and assists the Resident Care Director with the management of the community. The management scope includes direct supervision of Resident Care Associates as well as monitoring emerging health needs of...