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Associate Engineer, High Throughput Operations

3 months ago

Berkeley, United States Profluent Bio Inc. Full time

We are currently seeking a creative, passionate, and detail-oriented

Associate Engineer

to join the High Throughput Operations team. The focus of this role will be to develop and implement automated workflows for our in-house molecular cloning core, high throughput screening core, and NGS core. This candidate will work collaboratively with scientists, engineers, and bioinformaticians to develop a suite of assays for measuring gene editing activity and specificity.

This is an excellent opportunity to shape the future of AI-driven protein design and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, and gene editing.

Responsibilities

Provide regular maintenance, calibration, and troubleshooting procedures on liquid handlers, high throughput lab equipment, and other integrated systems

Work cross-functionally to develop and improve high throughput processes for molecular biology, bacterial/mammalian cell screening, and NGS workflows

Write verification and validation test protocols and deliver reports including IQ/OQ/PQ

Generate SOPs and reports for validated automation processes and assist with implementation

Provide onsite operator support for automated workflows

Develop tools, reporting and operational documents for tracking equipment spare parts, service calls, and repairs

Build and maintain relationships with vendors and third-party service providers

Qualifications

BS/MS in science or engineering discipline with 0-2 years of relevant experience

Hands-on experience operating liquid handling systems (e.g. Tecan Fluent, Hamilton Star, Agilent Bravo, Beckman Coulter Biomek)

Hands-on experience with protocol development and operation of gene assembly, cloning, mammalian screening, and NGS workflows

Experience with high throughput assay development and validation

Can adapt to changing project priorities and timelines

Strong oral and written communication skills

Excellent analytical, critical thinking, and soft skills to build collaborative relationships that enable effective professional interactions with vendors and stakeholders

Preferences (but not required)

High level of familiarity with gene editing systems, genome-wide assays to measure gene editing activity, specificity, and DNA repair outcomes.

Experience working with external vendors and third-party service providers

Some software development experience using python, C#, C++ or other programming languages

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