Scientist, Antibody Generation

3 months ago

Berkeley, United States Prellis Biologics, Inc. Full time

This role will report to the Director of Antibody Screening with accountability for supporting high-throughput antibody sequencing, cloning, expression, purification, and characterization workflows with a specific focus on single B-cell approaches.  The ideal candidate will have extensive expertise in these processes and a strong background in developing and applying high-throughput automation to accelerate the pace of therapeutic antibody development.

Key Responsibilities

Lead the optimization and execution of antibody generation workflows with expertise in antibody sequencing, molecular cloning, protein expression, and protein purification methods.

Lead the design, implementation, and management of automation protocols supporting high-throughput antibody sequencing, cloning, expression, and purification processes.

Manage the recombinant antibody production and purification workflows to generate broad panels of antibodies through innovative high-throughput cloning and selection approaches to ensure successful progression of pipeline projects

.  Collaborate closely with cross-functional teams to integrate automated systems into broader antibody discovery and development pipelines.

Train team members on the use of automated systems, ensuring that all users are proficient in operating equipment.

Stay current with industry trends in antibody generation and high-throughput automation; continuously assess and improve automated workflows to enhance efficiency and productivity.

Qualifications

Ph.D. or M.S. in Molecular Biology, Bioengineering, Biochemistry, Immunology, or a related field with relevant industry experience.

Extensive experience in molecular cloning, protein expression, and purification, with a strong focus on antibody generation and single B-cell technologies.

Strong understanding of antibody sequence recovery methods using NGS or 10X approaches.

Extensive experience in lab automation working directly with liquid handling platforms such as Hamilton, Tecan, Agilent, Beckman Coulter, PerkinElmer, or others in a biotech/pharma setting.

Knowledge of automation programming and/or scripting.

Excellent problem-solving skills with a strong focus on innovation and process optimization.

Significant ability to prioritize and manage multiple concurrent projects and tasks.

Strong communication skills, with the ability to present complex data to cross-functional teams. Strong technical writing skills and experience authoring SOPs, documentation, and training materials. 

Experience in scaling up workflows in an industry or research setting is a plus.

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