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Director, Medicinal Chemistry

4 months ago

Cambridge, United States Sail Biomedicines Full time

Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail’s platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. The Role: Sail Biomedicines is seeking a highly motivated and innovative

Director , to join the Chemistry Department and drive research in the field of lipid nanoparticle (LNP) and mRNA technology. As a leader within the Chemistry team, you will oversee and actively contribute to the design and synthesis of novel LNP components and oligonucleotides. You will closely collaborate with Formulations, Digital, and Artificial Intelligence (AI) teams to advance our programmable medicines. Responsibilities Provide strategic and technical leadership to drive the design and optimization of novel LNP components and synthetic mRNA components to advance Sail’s platform. Be a leader within the organization as one of the key representatives of the chemistry group. Manage and actively participate in synthesis, scale-up and analytics internally. Manage external CRO activities and assume responsibility for their productivity. With the AI teams, help develop machine learning models to aid in novel lipid design and optimization. Develop novel methods to characterize lipids and advance our understanding of the relationship between lipid structure, properties and LNP function. Work closely with our formulation and biology teams to assess novel lipids and incorporate new data in the design cycle. Contribute to CMC aspects as it relates to novel lipids. Lead the preparation of project specific patent documents as needed. Lead interdisciplinary teams towards milestone achievement for the Sail portfolio Provide mentorship, guidance, and support to direct reports in their professional development. Collaborate with internal stakeholders, including project management, intellectual property, and regulatory teams, to achieve project goals. Effectively communicate scientific findings, progress updates, and project strategies to senior management and external stakeholders. Qualifications: PhD in Chemistry or related discipline, with 10+ years of industry experience including experience in a leadership or managerial role and a strong publication record. Experience in lipid chemistry for RNA delivery is preferred, but not essential. Demonstrated strong synthetic chemistry expertise and proficiency in analytical techniques Team-oriented, execution-focused, and highly motivated, with strong work ethic. Ability to work independently, manage multiple projects concurrently, collaborate across disciplines and lead interdisciplinary activities to deliver project milestones. Strong verbal, written communication, and problem-solving skills. Ability to excel in a fast-paced, dynamic, innovative environment. Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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