Associate Director

2 weeks ago

South San Francisco, United States BioPhase Full time

Associate Director

$170-200K + bonus & equity

Responsibilities:

As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include:

  • Designing and executing in vitro and ex vivo studies to advance therapeutic programs.
  • Generating, analyzing, and interpreting complex data to establish functional PK/PD and efficacy relationships, elucidating the therapeutic mechanism of action for lead drugs.
  • Serving as the Disease Biology lead on multiple project teams, conducting and troubleshooting experiments, and collaborating cross-functionally to identify and mitigate risks for effective program advancement.
  • Contributing to the development of complex in vitro and ex vivo research and development capabilities.
  • Authoring and reviewing protocols, study reports, and regulatory documents to facilitate IND and other regulatory filings.
  • Following all company policies/practices and maintaining accurate records and notebooks.

Required Qualifications:

  • PhD in Endocrinology, Physiology, Diabetes/Obesity, Immunology/Inflammation, or a related biological science (MS with relevant years of experience).
  • At least 8 years of direct hands-on experience in therapeutic development leveraging indication-specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 12 years).
  • Hands-on experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g., IF/IHC/ISH), and/or flow cytometry.
  • Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays.
  • Proven ability to collaborate in writing protocols, reports, and regulatory documents.
  • Outstanding communication skills with a demonstrated ability to make effective presentations.
  • Experience with therapeutics programs that have yielded drugs entering clinical development in areas such as endocrinology, diabetes/obesity, immunology/inflammation, or metabolic disease.
  • Familiarity with microscopy, confocal imaging, or similar techniques.
  • Experience working as a subject matter expert with complex cell-based 2D/3D culture systems or ex vivo tissue models or patient-derived samples.
  • Ability to generate, analyze, and interpret multi-omic data sets.
  • Proficiency in establishing workflows, using Jupyter notebook or other platforms for bioinformatics analysis, and interpreting/visualizing complex data sets.
  • Previous experience leading a program in therapeutic discovery/development.
  • Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results.
  • Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams.
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