Group Leader, Metabolism

4 weeks ago


South San Francisco, United States CareerBuilder Full time

Company info
NewLimit is a biotechnology company working to radically extend human healthspan. Were developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description
NewLimit is seeking a liver biologist with leadership experience to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease.

In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.

As the leader of the Metabolism team, you will:

Lead a team of Scientists and Research Associates to develop epigenetic reprogramming therapies while remaining involved in day-to-day execution

Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes

Contribute to NewLimits product development decisions, company-wide goals, and technology platform

Serve as a company-wide expert on metabolic diseases and liver biology

Develop assays to measure hepatocyte function both

ex vivo

and

in vivo

Evaluate epigenetic reprogramming payloads using

ex vivo

and

in vivo

functional assays to select therapeutic candidates

Requirements

Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)

Experience leading a cross-functional team and managing direct reports

Experience with therapeutic development, as demonstrated through contributions to a pre-clinical or clinical stage program

Experience designing and executing experiments in animal models of liver dysfunction

Deep knowledge of metabolic disease, liver biology, and relevant therapeutic modalities

Nice to have

Experience with

in vivo

nucleic acid delivery technologies (e.g. viral vectors, endosomes, lipid nanoparticles)

Experience with bulk and single cell functional genomics methods

Experience with iterative product development cycles (e.g. design-build-test-learn)

Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:

Health, dental, and vision insurance

401(k) with company match

Paid parental leave

Industry-leading paid time off (PTO) 20 days/year for all employees + holidays

Meals and snacks on-site

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