Scientific Lead, Analytical and Mass-spectrometry
4 weeks ago
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
**Position Summary**:
**Roles and Responsibilities of the Position**:
- Perform sample prep on and support the overall development, optimization, and execution of analytical assays for protein characterization and bioanalysis.
- Support BioAnalysis sample preparation from complex matrixes (plasma/tissue) for mass spectrometry-based ligand binding assays.
- Flexibility in supporting and participating in new projects and contributing to changing deadlines.
- Prepare and analyze antibody/ADC samples for routine testing on analytical instruments such as RP-HPLC, SEC, LCMS (High Resolution and QQQ)
- Advance the LCMS and analytical capabilities of lab to gain insights into ADC designs and mechanisms of action
- Collaborate with the team to meet timelines and deliverables.
- Perform general lab maintenance and instrument calibrations.
- Maintain a high level of productivity in a laboratory setting.
**Required Qualifications**:
**Required**:
- A BSc and >8 years or MSc and >5 years of directly relevant experience with LC-MS in a drug development setting, or a PhD in a relevant scientific discipline (level commensurate with education and experience)
- Prior hands-on experience generating and interpreting LC-MS data to support large molecule drug programs is essential.
- High level of proficiency of Excel or prism, is required
- Excellent communication and interpersonal skills with strong organizational abilities
- Experience troubleshooting, maintaining of mass spectrometers and LC
- Proven track record in conceiving and implementing creative LCMS and other analytical solutions in the lab to advance the understanding of drug mechanism of action or developability
- Extensive hands on experience operating and maintaining Sciex 7500 Qtrap, Orbitrap, or other MS instruments.
- Previous work with antibodies, ADCs and other biotherapeutics and/or small molecule drugs
- Additional hands-on experience using analytical characterization such as SEC/HIC, U/HPLC, cIEF, CE, LC-MS, and cLIF is a plus
- Prior experience working with high capacity/throughput analysis of plasma and other samples is a plus
- Experience with high throughput plate-based assays (Working with automation is a plus)
- Experience developing and validating assays using LCMS targeted MS or proteomics techniques
- Experience analyzing and interpreting and reporting analytical data, along with sharing and presenting data to collaborators.
- Experience with and/or a deep understanding of PK and BioAnalysis of small molecule drugs or ADC biologic drugs
- Experience with R for data visualization is a plus.
- Demonstrated can-do attitude. Looking for someone that brings innovative ideas to challenging projects in a fast-paced, collaborative, and cross-functional organization
**Physical Demands/Travel**:
The physical demands of this job are consistent with a lab environment**.**
- The physical demands here are representative of those that must _be_ met _by an_ employee to_ successfully perform the essential functions of this job._
**Work Environment**:
This position’s work environment is in a Laboratory.
- The_ _work_ _environment_ _characteristics_ _descri_b_ed_ _here_ _are_ _representative_ of those an em_p_loyee encounters whil_e_ performing the essential _f_unctions of this job._
- _To perform this job successfully, an _individual_ must be able to perform_ the _role and responsibilities satisfactorily. The requirements _listed_ above are representative of the knowledge, skill, and/or ability _required._ Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions._
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more
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