Scientific Lead, Biophysical Chemistry
1 month ago
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
**Position Summary**:
- **Roles and Responsibilities of the Position**:
- Work with discovery, bioconjugation and engineering team members to screen, characterize and investigate (using analytical and biophysical platforms and methodologies) biologicals comprised of antibodies, ADCs, and other modalities, created for treatment of several oncological indications
- Independently design and execute key experiments for analytical and biophysical characterization of these large molecules from early discovery to early development stage that includes accelerated stability and developability assessments
- Interact and collaborate with other teams across the company to provide biophysical solutions; efficiently analyze, collate, and disseminate data to deliver results to teams in a timely manner consistent with project timelines
- Evaluate new and emerging analytical and biophysical techniques and instrumentation with the aim of expanding the capabilities and depth of molecular characterization provided by the biophysical chemistry team
- Participate and present periodic updates and reports to senior management to significantly influence strategic research decisions and operations
- **Required Qualifications**:
- PhD with 0-5 years exp post-doc/academic research/industry exp MS degree with 6+ years industry experience BS degree with 8+ years industry experience
- Previous industry/academic/research experience with good understanding of drug development process of therapeutic antibodies, antibody conjugates, bi and multi-specific molecules and other modalities.
- Knowledge and hands-on experience with biophysical techniques and platforms for characterization of stability, purity and quality of biologics, such as dynamic light scattering (DLS), static light scattering (SLS), capillary isoelectric focusing (cIEF), size exclusion chromatography (SEC), multi-angle light scattering (MALS), ion exchange chromatography (IEX), hydrophobic interaction chromatography (HIC), CE-SDS, and SDS-PAGE.
- Hands-on experience in characterization of biomolecular interactions using various industry standard technologies (e.g. SPR, BLI) and other relevant technologies for characterization of high/low affinities, active concentrations, cross-blocking, heterogeneities, and other product defining characteristics
- Being highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills.
**Additional Preferences**:
- Previous experience with purification and characterization of bispecifc, multispecific antibodies, and/or ADCs
- Experience in lead optimization
- Experience with cell binding technologies such as flow cytometry, Ligand Tracer, or Real-Time Interaction Cytometry
- Experience in laboratory automation for liquid handling and screening
- Experience with spectroscopic techniques for characterization of biomolecules (e.g., UV/Fluorescence)
- Hands-on experience with vendor provided software for biosensor data analysis and visualization. Experience with additional software tools such as Graphpad Prism, R, Matlab, Spotfire etc.
- Prior experience participating in team efforts for antibody lead panel generation, lead optimization and IND enabling studies
- Previous experience supervising & mentoring scientists, setting expectations and providing clear direction
- Must have a can-do attitude to take on challenging projects and to meet project timelines
- Have excellent communication skills and strong organizational abilities
**Physical Demands/ Travel**:
Travel: TBD
- The physical demands here are representative of those that must _be_ met _by an_ employee to_ successfully perform the essential functions of this job._
**Work Environment**:
This position’s work environment is in a lab setting
- The work environment characteristics descri_b_ed here are representative of those an em_p_loyee encounters whil_e_ performing the essential _f_unctions of this job._
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Networ
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