Scientist, Molecular Biology, Functional Genomics
4 weeks ago
**Responsibilities**
- Carry out CRISPR/Cas9 functional genomics assays (e.g., Perturb-seq, CRISPR screens, etc.) in organoid cancer models to unravel mechanism of action and enable novel targets validation
- Perform cell culture for functional assays related to drug response in cell and organoid models
- Ability to conduct a wide variety of molecular biology and NGS-based techniques with mínimal supervision and with an exceptional attention to details
- Lab operations include RNA/DNA extraction/purification, NGS library preparation & QC
- Work independently and/or in collaboration with other team members on novel NGS workflows
- Generate, organize, and maintain meticulous records of all conducted experiments
- Track NGS collaborative research inquiries, projects, action items, deadlines and organize all supporting information for NGS projects
- Coordinate sample transfer through data delivery for experiments performed in-house and/or via external organizations
- Review extraction, sequencing run and data quality control stats and documenting them for future reference
- Excellent time management and organizational skill with attention to details
- Self-motivated, strong communication skills, both written and oral. Strong ability to work in a fast-paced environment is essential. Strong interpersonal and communication skills with a demonstrated ability for creative thinking and problem solving.
- Maintain laboratory notebook and prepare written data reports, figures, and presentations of the research in the form of progress reports, manuscripts, and/or internal and external research presentations
**Skills/Knowledge preferred**
- PhD or MS degree with 4+ years of professional experience in molecular biology (preferred), biology, biotechnology, or biochemistry
- Extensive understanding of NGS technologies (e.g., DNA-seq, RNA-Seq, and single-cell mRNA-Seq), with a track record of utilizing such assays and an ability to troubleshoot the sequencing process end-to-end to improve NGS library quality
- Strong knowledge of CRISPR tools and their integration with NGS technologies
- Demonstrated expertise in molecular biology techniques, including DNA/RNA extraction & purification, NGS library preparation & QC, PCR, qPCR, cloning, etc.
- Experience with single-cell sequencing workflows, such as 10x Genomics
- Strong understanding of theory behind techniques, proficient reasoning skills in experimental design and optimizing wet lab techniques, coupled with an exceptional attention to details
- Understanding of Illumina sequencing data and ability to interpret secondary data analysis metrics
- Competence with standard cell isolation, cell culture, compound treatment, FACS
- Excellent troubleshooting and problem-solving skills
- Commit to quality by rigorous and constant evaluation of own work
- Proficiency with MS Office suite, and ability to analyze and present genomic data
- Strong planning and organizational skills and comfort with systems such as Confluence, JIRA, or SharePoint systems
**Additional Responsibilities**:
- Drive the implementation and utilization of novel genomics assays across diverse research programs
- Foster impactful collaborative genomics initiatives within the organization
- Must be a strong team player with a proactive and positive attitude
- Ability to use technical skills and good time management to perform work efficiently and meet project timelines
**Application Requirements**:
- Cover Letter (optional)
- Curriculum Vitae
**Job Type**: Contract
Pay: $54.00 - $62.00 per hour
Expected hours: 40 per week
Schedule:
- 8 hour shift
- Monday to Friday
**Experience**:
- Molecular biology: 5 years (required)
Ability to Commute:
- San Diego, CA 92122 (required)
Ability to Relocate:
- San Diego, CA 92122: Relocate before starting work (required)
Work Location: In person
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