Development Scientist Ii, Analytical Development

5 days ago


New Haven, United States Alexion Pharmaceuticals,Inc. Full time

Location: New Haven, United States

Job reference: R-198974

Date posted: 05/06/2024

**This is what you will do**:
**You will be responsible for**:

- Leading and performing protein characterization (method development and analysis) by LC/MS.
- Oversee and train associates to perform method development and analysisby LC/MS.
- Participate in cross-functional development teams representing the Protein Characterization group and lead scientific/technical problem-solving efforts with the group.
- Authoring CMC sections for regulatory, technical reports, department-specific protocols and reports, and general operating procedures. Leading the development and authoring of new procedures and work practices.
- Lead new technology evaluation and independently developing protein characterization strategies.
- Manage the activities of external research laboratories.

**You will need to have**:

- Deep understanding and extensive hands-on experience with protein characterization by LC/MS using multiple mass spectrometry instruments and platforms.
- Ability to lead problem solvingactivities and bring independent, scientific approaches to method development.
- A thorough understanding of GLP and quality guidelines; and ability to lead process improvements.
- The individual must be able to give clear instructions, train, and oversee personal as required on practices within the laboratory. Planning and organizing skills are required to plan, execute, and track commitments of the laboratory and to adjust to changing priorities.
- An understanding of the “big picture” for projects and tasks involved, and prioritize work of self and others accordingly.
- The duties of this role are conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

**We would **prefer** for you to have**:

- PhD in Biochemistry, Chemistry or related discipline and a minimum of 2-5 years related experience.
- In-depth knowledge of charge variant analysis.
- In-depth knowledge of additionalnon-MS methods and instrumentation for testing biotherapeutics.
- Experience with development, optimization, qualification, and validation biotherapeutic assays.
- Experience working with CRO’s for developing assays and testing of samples.

**In-person statement for 4 days in the office**:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of four days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



  • New Haven, United States Alexion Pharmaceuticals,Inc. Full time

    Location: New Haven, United States Job reference: R-201669 Date posted: 06/06/2024 **This is what you will do**: The Development Scientist I position is a technical position responsible for development and optimization of release and stability methods including physicochemical methods pertaining to Imaged Capillary Electrophoresis (icIEF) as well as...


  • New Brunswick, New Jersey, United States Bristol Myers Squibb Full time

    Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the...


  • New Brunswick, United States Bristol Myers Squibb Full time

    Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the...


  • New Haven, United States Alexion Pharmaceuticals, Inc. Full time

    This is what you will do: The Associate scientist II will join Injectable Drug Product Development group to support the development of Alexion's biotherapeutic candidates. This individual will design and execute experiments to develop injectable drug product formulations and process characterization studies, including analyzing samples and authoring...


  • New Brunswick, United States Bristol-Myers Squibb Full time

    **Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...


  • New Haven, United States Alexion Pharmaceuticals, Inc. Full time

    This is what you will do: The Analytical Development Senior Scientist position is a technical position responsible for supporting Analytical and Process Development with early and late phase LC methods including process residuals and physiochemical chromatography (size exclusion, ion-exchange, reversed phase, hydrophobic interaction, etc.) in support of DS...


  • New Haven, United States Alexion Pharmaceuticals, Inc. Full time

    This is what you will do: * Lead and perform mass spectrometry characterization of biotherapeutics from discovery to marketed products. The candidate should be an expert and leader in characterizing antibodies, proteins, and peptides by mass spectrometry. This includes, but is not limited to, intact molecular weight analysis, subunit analysis, peptide...


  • New Haven, United States Alexion Pharmaceuticals Full time

    This is what you will do: The Analytical Development Senior Scientist position is a technical position responsible for supporting Analytical and Process Development with early and late phase LC methods including process residuals and physiochemical chromatography (size exclusion, ion-exchange, reversed phase, hydrophobic interaction, etc.) in support of...


  • New Haven, United States Alexion Pharmaceuticals, Inc. Full time

    This is what you will do: * The Development Scientist I position is a technical and bench position responsible for development, qualification, and characterization of ligand binding assay (ELISA or other homogeneous methods) and process-derived Residual DNA assay to support process development and GMP release of Alexion's biotherapeutic products. * This...


  • New York, United States Amazon Development Center U.S., Inc. Full time

    PhD, or Master's degree and 4+ years of CS, CE, ML or related field experience - Experience programming in Java, C++, Python or related language - Experience in program analysis, program synthesis, or neural deep learning methods and machine learning AWS Utility Computing (UC) provides product innovations — from foundational services such as Amazon’s...


  • New Bedford, Massachusetts, United States Obsidian Therapeutics Full time

    Senior/Principal Scientist, Viral Vector Analytical DevelopmentBedford, MAAbout Us...Obsidian Therapeutics is expanding the reach of TIL therapy. We are pioneering engineered tumor infiltrating lymphocyte (TIL) therapies to deliver transformative outcomes for patients suffering from solid tumor malignancies. Obsidian's programs apply our cytoDRiVE platform...

  • Scientist Ii

    4 weeks ago


    New York, United States BlueRock Therapeutics Full time

    **Who is BlueRock?** BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique **_cell+gene_** platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations...

  • HR BI Developer II

    4 weeks ago


    New Haven, United States Yale New Haven Health Full time

    OverviewTo be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values. These values - integrity, patient-centered, respect, accountability, and compassion - must guide what we do, as individuals and professionals, every day. The BI Developer II is responsible for creating reports,...


  • New Haven, United States Alexion Pharmaceuticals,Inc. Full time

    Location: New Haven, United States Job reference: R-199822 Date posted: 05/16/2024 **This is what you will do**: **You will be responsible for**: - Designing safe and scalable synthetic routes that decrease costs, optimize process efficiency, and enhance product quality. - Designing multi-step continuous drug substance manufacturing processes and...


  • New Haven, United States Alexion Pharmaceuticals Full time

    This is what you will do: The Associate Scientist III is responsible for performing assigned experimental tasks to support the development and optimization of cell line development and cell culture processes for Alexion’s therapeutic protein candidates. The Associate Scientist III will work in collaboration with other members of Product Development and...


  • New Brunswick, United States Bristol-Myers Squibb Full time

    **Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...


  • New Haven, United States Yale New Haven Health Full time

    Overview To be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values. These values - integrity, patient-centered, respect, accountability, and compassion - must guide what we do, as individuals and professionals, every day. The Chief Development Scientist will supervise the...


  • New York, New York, United States BlueRock Therapeutics Full time

    Who is BlueRock?BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from...


  • New Brunswick, United States Pioneer Data Systems Full time

    Position Details: Our client, a world–leading Pharmaceutical Company in New Brunswick, NJ is currently looking for a Healthcare Data Scientist (PhD / DrPH) to join their expanding team. Job Title: Healthcare Data Scientist (PhD / DrPH) / Pharma Industry Duration: 12 months contract, extendable up to 24 months Location: New Brunswick, NJ Hybrid:...

  • Senior Scientist II

    1 month ago


    Winter Haven, Florida, United States IFF Family of Companies Full time

    Requisition ID : 492026 Job Description Do you want to drive R&D in the field of citrus? It is an exciting time to be part of IFF We are looking for a Senior Scientist, Analytical Chemistry Citrus Innovation to join our NOURISH Business Unit Team. The function will be at our New Citrus Innovation Center in Lakeland, Florida starting in the 1st quarter of...