Mass Spectrometry Team Leader

3 weeks ago

Austin, United States Dept of State Health Services Full time

Chemist IV
- Under mínimal supervision of the Newborn Mass Spectrometry Group Manager the Team Leader oversees the daily activities of the Newborn Mass Spectrometry Team. They will use expert knowledge to independently perform and monitor highly complex tandem mass spectrometry (MS/MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis on high volume neonatal specimens to screen newborns for amino acid, fatty acid oxidation and organic acid disorders and other disorders as required. Responsible for independently performing specimen preparation, quality control, and assay acceptability, data and work list evaluation, result entry, release of final results, maintenance and troubleshooting of equipment. Utilizes expert working knowledge of all procedures to independently determine, troubleshoot and release complex results ensuring that analytic accuracy is maintained. Serves as an authority and role model. Responsible for making significant decisions on the accuracy of laboratory tests on human specimens. Actively participates in instrument and method evaluation, validation and optimization. Actively participates in the safety program. Monitors and documents quality assurance parameters. Responsible for monitoring staff, training personnel and providing customer service. Duties are performed with significant latitude and with extensive use of scientific knowledge and independent judgment.

**Essential Job Functions**:
Attends work on a regular and predictable schedule in accordance with agency leave policy and performs other duties as assigned.
- EJF 1. Oversees the daily activities of the Newborn Tandem Mass Spectrometry. Monitors staff activities and daily timelines notifying the Group Manager immediately of any significant issues or delays. Ensures high quality of analytical reporting is maintained in the Newborn MS/MS Laboratory by performing and documenting periodic quality control review, equipment performance, specimen workload tallies, training records, and supply inventory to ensure consistently acceptable quality assurance and test performance. Identifies discrepancies and recommends, implements and documents corrective actions and outcomes. Participates in the update and development of Standard Operating Protocols (SOP) and training materials. Assists with the evaluation, optimization, validation and implementation of MS/MS and LC-MS/MS methods to screen neonatal screening specimens. Consults with and keeps Group Manager up to date on method performance and technical issues. (25%)
- EJF 2. Evaluates and interprets highly complex data assigning final results. Uses expert knowledge to investigate, interpret, assess, review, and resolve problems with atypical results, consulting with the Group Manager as necessary. Reviews and releases final results using the laboratory information management system. Identifies, documents, and resolves quality issues with laboratory data. Cross-checks positive mailed report verifying abnormal reports are correct. Monitors that preparation of final report timelines are met including panic level fax reports to the Clinical Care Coordination staff. (20%)
- EJF 3. Ensures MS/MS instruments and equipment, including laboratory information system equipment, are maintained for optimum performance and minimum downtime. Schedules equipment preventive maintenance according to standard operating procedures. Maintains equipment records and reviews instrument performance. Ensures equipment preventive maintenance is completed per schedule. Performs routine and specialized preventive maintenance of highly complex tandem mass spectrometry instruments, and other equipment. Perform complex data analysis to determine acceptable instrument and method performance. Performs instrument tuning and optimizations as necessary. Identifies and documents instrument and equipment problems, performs troubleshooting, makes adjustments as indicated, consulting with group manager and requesting vendor support as needed. (20%)
- EJF 4. Performs highly complex MS/MS and LC-MS/MS analysis on high volume neonatal screening specimens. Performs, as needed, high volume sampling of filter paper specimens, standards, and controls for all newborn screening tests. Uses technical knowledge to determine specimen acceptability. Completes all documentation with required information. (15%)
- EJF 5. Serves as a knowledgeable resource to laboratory personnel in the NBS MS/MS laboratory on difficult instrumentation and analytical issues. Performs administrative functions including completing regular reports and ad hoc reports, attending meetings and storing records. Notifies supervisor of technical or personnel problems that impact the functioning of the laboratory. Ensures adequate inventory of supplies and reagents to prevent delays in critical testing services. Participates in preparing team budgets, assessing equipment and staffing requirements. Trains employees on instrument maintenance and on pe

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