LC Mass Spectrometry Scientist

Job Description:
Chemist III
Under limited supervision of the Mass Spectrometry Screening Group Manager and the Second-Tier Mass Spectrometry Screening Team Lead uses considerable knowledge to independently perform highly complex tandem mass spectrometry (MS/MS) and liquid chromatography-tandem mass spectrometry analysis on high volume neonatal screening specimens. Serves as an authority on test procedures in the laboratory. Utilizes considerable working knowledge of all procedures to participate in maintaining analytic accuracy and precision. Responsible for monitoring and independently performing specimen preparation. Responsible for analysis, quality control and assay acceptability, data and work list evaluation, result entry, release of final results, maintenance and troubleshooting of equipment, proper record keeping and training of personnel. Responsible for making significant decisions on the accuracy of laboratory tests on human specimens. Independently determines and releases complex results based on Standard Operating Protocols (SOP). Actively participates in the safety program. Group Manager or Team Lead will assign a small portion of daily work providing general instruction for routine tasks and detailed instructions for non-routine tasks. Duties are independently performed with considerable latitude, adherence to standard protocol and with use of scientific knowledge and independent judgment. Essential Job Functions:
Attends work on a regular and predictable schedule in accordance with agency leave policy and performs other duties as assigned.

Attends work on a regular and predictable schedule in accordance with agency leave policy and performs other duties as assigned.
EJF 1. Performs highly complex MS/MS and LC-MS/MS analysis on neonatal screening specimens adhering to standard operating protocols. Performs sample extraction and preparation of internal standards and test solutions. Assists with training Branch staff to complete technical procedures. Monitors and completes proper record keeping and documentation involved with analytical testing and specimen flow. Collates and files electronic and raw results according to DSHS record retention policies. (30%)

EJF 2. Evaluates and interprets highly complex data. Identifies problems with atypical test results consulting with Team Lead or Group Manager and ensuring final result is captured and reported. Reviews and releases final results. Uses Newborn Screening laboratory information management system. Completes and maintains proper record keeping and documentation involved with data evaluation and interpretation. (25%)

EJF 3. Performs routine and specialized preventive maintenance of highly complex equipment. Identifies equipment problems, performs troubleshooting and makes routine adjustments as indicated. Performs instrument tuning and post maintenance checks. Monitors and performs calibration verifications of liquid handling and other equipment on a scheduled basis. Completes logs, checklists and other record keeping documentation associated with equipment maintenance and instrument performance. Verifies equipment is operating properly and immediately consults with team lead or Branch Manager when difficult problems arise, assisting with resolution. (20%)

EJF 4. Performs sampling of filter paper specimens, standards, and controls for newborn screening tests adhering to standard operating protocols. Uses technical knowledge to determine specimen acceptability. Completes proper record keeping and documentation involved with specimen and standards preparation. Preserves samples and standards according to standard operating protocol. (10%)

EJF 5. Promotes workflow through cooperative interaction, reassignment of duties, and teamwork with supervisor, co-workers, and internal and external customers. Initiates and delivers rapid communication of abnormal test results to Clinical Care Coordination staff for same day follow-up. Recognizes delays in completion of specimen testing, result reporting, and other essential functions and notifies the lead technologist or Branch Manager immediately. Manages assigned work to meet specimen testing, reporting, and other essential functions in a timely manner. Conducts training and tours as assigned. (5%)

EJF 6. Actively participates in quality control review, proficiency testing, equipment performance documentation, specimen workload tallies and supply inventory to ensure consistently acceptable quality assurance and test performance. Assists in developing procedures for processing specimens to ensure the accuracy of the results and proper handling of specimens. (5%)

EJF 7. Monitors and performs other duties such as disposing biological and hazardous wastes, general housekeeping, verifying standard expiration dates and volumes, verifying specimen preservation, verifying refrigerator temperatures and verifying laboratory hoods are functioning properly. Employs safe laboratory practices to protect self and others in the laboratory, checks proper functioning of eyewash stations and other safety equipment. Based on work area, consistently comply with DSHS Laboratory, local, state and federal guidelines to ensure a safe functioning laboratory. Performs other duties not specified in the job description, if necessary, as directed by the Group Manager or Team Lead. Other duties as assigned include but are not limited to actively participating and/or serving in a supporting role to meet the agency’s obligations for disaster response and/or recovery or Continuity of Operations (COOP) activation. Such participation may require an alternate shift pattern assignment and/or location. (5%)
Knowledge Skills Abilities:
Advanced Knowledge and skill in laboratory, clinical chemistry, quality control, quality assurance, MS/MS and LC-MS/MS principles, techniques, and terminology.
Knowledge of laboratory safety including sample-handling techniques.
Ability to communicate effectively orally and in writing.
Ability to follow written and verbal instructions.
Ability to interact effectively with staff.
Ability to work in harmony with other team members.
Ability to work as part of a team adhering to structured deadlines for completion of critical laboratory procedures that are performed in high volume.
Ability to lead co-workers by setting a positive work-ethic example.
Ability to follow standard operating procedures and protocols accurately.
Ability to keep accurate, detailed records.
Ability to use aseptic techniques when working with infectious material.
Ability to complete tasks without close supervision and use mature judgment in test interpretation.
Ability to prioritize and organize detailed tasks to maintain required section timeframes.
Ability to recognize and solve work area problems.
Ability to use, maintain and troubleshoot work area instruments and automated testing equipment.
Ability to teach work area procedures to co-workers and guests.
Ability to prepare diagnostic (analytical) reagents and/or controls accurately.
Ability to plan, assign, direct and monitor the work of others.
Ability to work independently and make technical decisions based on professional knowledge and experience.
Ability to use a computer for word processing, spreadsheet and database analysis, and results reporting.
Skill to manipulate standard laboratory equipment with speed, accuracy and safety.

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