Scientist I, Molecular Biology and Expression

1 week ago

South San Francisco, United States Soleil Labs, LLC Full time

**Scientist I** MOLECULAR BIOLOGY AND EXPRESSION, PROTEIN SCIENCES**:
**April 2024**:
**Department**:Technology**:
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**Work Location**: Corporate Headquarters (South San Francisco)**:
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**Position Summary**:
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**Responsibilities**:

- Perform molecular biology techniques including high throughput PCR and molecular cloning, and from small to large scale plasmid DNA purification.
- Design and generate recombinant antigen protein expression plasmid for bacterial and mammalian expression systems.
- HTP transient expression of antibodies in mammalian cell lines on automated platform.
- Develop and generate antibody stable expression in CHO and 293.
- Accurately and consistently record experimental methods, materials, and results.
- Provide regular progress updates and present data at internal team meetings and departmental meetings.

**Qualifications**
- M.S. in Molecular Biology, Chemical Biology, Biochemistry or other relevant discipline with 5+ years of relevant experience, or B.S. with equivalent experience.
- Self-motivated and passionate about automation and new technology.
- Extensive hands-on experience with prime design and PCR.
- Experienced with various molecular cloning methods such as seamless and GoldenGate cloning is required.
- Extensive hands-on experience with transient mammalian expression (HEK293 and CHO) is required.
- Hands-on experience with automation using liquid handler is highly desired.
- Experience with recombinant protein expression in bacterial and/or other expression system is highly desired, especially good understanding on solubility enhancing techniques.
- Hands-on experience with stable mammalian expression (HEK293 and CHO) is desired.
- Hands-on experience of mono
- and bi-specific antibodies, Fab fragments, scFv, VHH, and various antibody-fusion formats is desired.
- Strong organizational skills and ability to handle multiple projects simultaneously.
- Comfortable to work in a fast-paced work environment.

**Company Overview**

TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

**EEO Statement**

**Benefits and Compensation**

TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

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