Scientist I, Radiochemistry

3 weeks ago

San Diego, United States Bristol-Myers Squibb Full time

**Working with Us**
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

**Location**:San Diego

**Background**

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC) and breast cancer. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

**Summary**

The Scientist will be responsible for conducting research, experiments, and analysis in the field of radiochemistry. This role involves radiolabeling of diagnostic and therapeutic radioisotopes of peptides, small molecules, and/or antibodies as well as quality testing for in vitro and in vivo work. The Scientist will work in laboratory settings, collaborating with interdisciplinary teams to advance scientific knowledge and contribute to the advancement of all RayzeBio's internal programs.

**Responsibilities**:
Essential duties and responsibilities include the following. Other duties may be assigned.
- Develop and optimize experimental procedures ad methods, as well as conduct experiments to radiolabel peptides, small molecules and/or antibodies using various isotopes including but not limited to: Lu-177, Ac-225, Cu-64, Ga68 and Zr89
- Develop and execute methods for the characterization of radiolabeled compounds, using techniques such as radio-HPLC and radio-TLC chromatography to analyze purity and stability
- Develop novel methods and conduct in vitro assays (e.g. plasma stability and metabolite analysis) with radiolabeled compounds
- Prepare compounds for cell-binding assays and in vivo biodistribution and dosimetry studies
- Evaluate and present all radiolabeling methods and analytical results in functional meetings to provide input to progress internal programs
- Develop, interpret, and maintain appropriate documentation using GxP guidelines, including radiolabeling protocols, reports and data analyses
- Maintain a clean and safe working environment

**Education and Experience**
- A Ph.D or Master's degree in radiochemistry, chemistry, nuclear chemistry, or related field
- A minimum of 5 years of experience in radiochemistry, radiopharmaceutical, and/or CMC development field
- Demonstrated experience in radiochemistry techniques and quality control instruments including but not limited to radioHPLC, TLC, gamma counter, gamma spectroscopy
- Proper radiation safety practices during radiosynthesis, radioanalytical chemistry operations, and when physically within the lab areas at all times
- Ability to work both collaboratively and independently in a fast-paced and cross-functional environment

**Skills and Qualifications**
- Hands on experience working with radioactive materials and radiation instrumentation in a radiochemistry laboratory setting.
- Highly motivated and organized professional with the ability to work both with a team and independently
- Multi-disciplined scientist with ability to troubleshoot
- Excellent professional ethics, integrity, and ability to maintain confidential information

**Uniquely Interesting Work, Life-changing Careers**

**On-site Protocol**

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles th

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