Scientist I/ii, Process Development

2 months ago

South San Francisco, United States AbbVie Full time

**Company Description**

**Key Accountabilities/Core Job Responsibilities**
- Perform routine tasks such as media/buffer preparation, thawing of cryopreserved cells, cell culture passaging, aseptic sampling and banking competently and independently to support ongoing projects in cell culture lab
- Take routine analytical measurements for cell growth, gas-content analysis, pH, osmolality, nutrient and metabolite measurements and HPLC analysis of monoclonal antibody titers
- Utilize technical expertise and available information to troubleshoot and resolve operational hurdles when encountered and adapt protocols as necessary
- Propose novel scientific experiments in mammalian cell culture
- Collaborate across CMC functions to optimize bioprocess parameters for the production of difficult-to-manufacture biologics
- Execute high-throughput fed batch and batch experiments and perform data analysis of the same
- Able to maintain a “can-do” attitude to complete innovative projects while being flexible in work priorities based on business needs
- Perform tasks with rigorous attention to detail consistently. Prioritize tasks and contribute to a highly motivated and productive team with a sense of urgency and desire to meet project timelines
- Accurately document, critically analyze/interpret data and communicate the results promptly through various electronic means
- Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials
- Must be comfortable with physical activities of constant standing, walking, and sitting with arm stretching into biosafety cabinets for cell culture work and occasionally lifting 50Ibs.
- Strong interpersonal skills to thrive in a team environment

**Qualifications**
- Prior experience in bioreactor operation and cell culture media preparation is a must
- Industry experience in sterile fermentation techniques preferably mammalian cell culture
- Experience in single use mammalian cell culture tools employed in bioprocess development, including but not limited to deep well plates, shake flasks, ambr250s, stirred tank reactors
- Excellent aseptic techniques and familiarity with principles of sterilization/disinfection.
- Familiar with general troubleshooting techniques and implementation of quality controls in developmental lab
- Experience with process development, optimization, and troubleshooting
- Experience in setting up high throughput experiments in both fed batch and batch modes, and comfortable with automation and manual operation when needed.
- Comfortable with practical considerations needed to successfully scale up conditions tested in high throughput systems to larger scales
- Excellent communication skills and experience using collaborative cloud-based technologies to in a hybrid working environment.
- Able to maintain instrumentation, inventory and cleanliness of a developmental lab to create a safe, effective and efficient scientific working environment.
- Familiarity with the use of single use mammalian cell culture technologies such as deep well plates, shake flasks, ambr250s, stirred tank bioreactors

**Additional Information**
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

Can hire at either level depending on performance.

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