Sr. Scientist I/II

Sr. Scientist I/II - Targeted Therapeutics Job Category: Research Requisition Number: SRSCI001883 Apply now Posted : September 23, 2025 Full-Time On-site Locations Showing 1 location Headquarters9704 Medical Center DrRockville, MD 20850, USA Headquarters9704 Medical Center DrRockville, MD 20850, USA MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe. The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization. Summary of Position: The Senior Scientist I/II will be an integral member of the Targeted Therapeutics Group focused on generating novel antibody-based therapies for the treatment of cancers. The incumbent will be responsible for the design and synthesis of novel linker-payload molecules, and the execution of experiments to support the progression of our novel antibody-drug conjugates (ADCs) from lead generation through pre-clinical development, achieving key program milestones and timeline goals. The role also involves driving innovation by staying current with the field and scouting new technologies to advance discovery efforts. Responsibilities and Job Duties: Lead efforts to establish and expand internal medicinal chemistry capabilities, to support ADC discovery and development. Design, synthesize, and optimize novel linker-payload molecules, directly contributing to next-generation ADC therapies. Perform and optimize bioconjugation reactions. Purify, characterize, and analyze synthesized molecules using analytical techniques such as HPLC, FPLC, LC-MS, and NMR. Collaborate closely with cross-functional teams to advance ADC programs from early discovery through preclinical and clinical development stages. Analyze, interpret experimental results, and present key findings and strategic insights at team meetings and to senior leadership. Author protocols, research reports, and intellectual property documents, while maintaining high-quality electronic laboratory records. Champion external visibility for our science and technology through participation in scientific meetings and symposia. Qualifications Senior Scientist I Minimum Education & Other Credentials Bachelor’s degree in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with 8 or more years of direct, relevant experience. Master’s degree in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with 5 or more years of direct, relevant experience. Ph.D. in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with direct laboratory experience. Postdoctoral experience preferred. Senior Scientist II Minimum Education & Other Credentials Bachelor’s degree in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with 11 or more years of direct, relevant experience. Master’s degree in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with 8 or more years of direct, relevant experience. Ph.D. in Organic Chemistry, Medicinal Chemistry, or Peptide Chemistry, with 3 or more years of direct, relevant experience. Postdoctoral experience preferred. Knowledge, Skills and Abilities Strong foundation in organic chemistry, medicinal chemistry, and/or peptide chemistry, with a passion for applying this expertise to therapeutic innovation. Hands-on experience in designing, synthesizing, and optimizing novel linker-payload molecules. Experience with protein conjugation, purification, and ideally ADC generation. Proven expertise in protein analytical methods such as HPLC, HIC, SEC, ion exchange, and LC-MS, with the ability to generate high-quality data to drive decision-making. Background in ADCs and bioconjugation is highly desirable, though not required for motivated candidates eager to grow in the field. Detail-oriented and well organized with strong written and verbal communication skills. Ability to positively impact company culture and demonstrate flexibility in a fast-paced, multi-disciplinary collaborative environment. Strong track record of executing experiments, developing assays, optimizing protocols, and interpreting results to drive impactful discoveries. Commitment to maintaining accurate, timely, and high-quality lab records. Independent, self-motivated, and team-oriented, with a track record of innovation, critical thinking, and problem solving. Supervisory Responsibilities Potential for supervisory and leadership responsibilities as the team expands. Preferred Qualification: Direct experience in designing, synthesizing, and optimizing novel linker–payload molecules. Proven expertise in antibody conjugation, purification, and characterization. Experience with biochemical techniques to assess drug potency is a plus. Hands-on experience in the field of targeted protein degradation. Additional Information The annual rate of pay for this position ranges from $99,200 - $151,300 (Sr. Scientist I) and $113,900 - $173,800 (Sr. Scientist II). For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company’s discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company’s benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits. The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate’s experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law. Statement MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and/or 711 for TTD/TTY service. Equal Opportunity EmployerThis employer is required to notify all applicants of their rights pursuant to federal employment laws.For further information, please review the Know Your Rights notice from the Department of Labor. #J-18808-Ljbffr