TalentCraft | Senior Scientist, DMPK | chicago, il

1 month ago


chicago, United States TalentCraft Full time

Position: Senior Scientist, Drug Metabolism/Pharmacokinetics (DM/PK)

Role Summary

Seeking a Senior Scientist to advance our research in Drug Metabolism/Pharmacokinetics (DM/PK). This key position will drive in vivo evaluations of therapeutic candidates, focusing on pharmacokinetics, metabolism, and bioavailability of novel compounds. The role requires a strong DM/PK background, extensive in vivo testing experience, and the ability to design studies and influence drug discovery strategy.

Primary Responsibilities

  • Independently design and conduct in vivo pharmacokinetic studies to assess drug candidates' metabolism and bioavailability using various animal models, with an emphasis on mouse models for cancer therapeutics.
  • Develop experimental protocols and oversee the IACUC review/approval process.
  • Collaborate with interdisciplinary teams, including chemists and biologists, to integrate DM/PK data across the drug discovery and development stages.
  • Manage and mentor laboratory technicians, guiding experimental techniques and ensuring smooth lab operations.

Qualifications

  • Education: M.S. or Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmacology, or a related field.
  • Experience:
  • M.S. with 10+ years of relevant postdoctoral DM/PK experience or Ph.D. with 5+ years; industry experience is preferred.
  • Extensive experience in in vivo pharmacokinetics, including study design, execution, and data analysis.
  • Skilled in in vivo procedures, such as administering test molecules to mice, tissue collection and processing, and histology techniques, including H&E staining.
  • Proficient in data analysis tools like WinNonlin, Phoenix, or similar PK/PD modeling software.
  • Demonstrated scientific contributions, including peer-reviewed publications.

Core Competencies

  • Problem-solving ability with a hands-on approach in a laboratory setting.
  • Strong team collaboration skills within a multidisciplinary research environment.
  • Excellent communication skills, with proficiency in presenting complex data to various stakeholders.



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