Associate Scientist, Peptide Chemistry
1 week ago
Job Description:
We are seeking a highly skilled and motivated Scientist with a strong background in synthetic chemistry, peptide chemistry and solid-phase peptide synthesis. This role is primarily lab-based, focused on design, synthesis and biochemical characterization of preclinical compounds for oncology applications. If you are a skilled and enthusiastic chemist, eager to contribute to the discovery of novel therapeutics, we encourage you to apply and become a part of our team.
Key Responsibilities:
- Design, synthesize, purify, and characterize peptide starting materials that will serve as building blocks for our proprietary Precision-Linked Proteomimetics.
- Characterize compounds using analytical methods including HPLC, LC-MS, NMR and other relevant analytical methods.
- Conduct biochemical assays to determine target-binding potency of starting-point peptides and PLP compounds.
- Execute experimental plans, troubleshoot synthetic challenges, and optimize peptide characteristics (physicochemical properties, target binding, etc.).
Required Skills and Experience:
- Ph.D. with 2+ years of industry/postdoctoral experience or MS with 3+ year of industrial experience in a relevant scientific field (Chemistry, Biochemistry, Medicinal Chemistry, etc.) with a strong academic track record.
- High degree of proficiency in synthetic organic chemistry with experience in peptide chemistry and solid-phase peptide synthesis.
- Experienced with compound purification and characterization methods such as HPLC, LC-MS, NMR, and MALDI.
- Experience with peptide design, including SAR studies and optimization.
- Expertise in in vitro biochemical assay design and execution (SPR, BLI, TR-FRET, MST, etc.).
- Experience applying computational methods to designing compounds is a plus.
- Knowledge of automation and validation of assays for HTS is a plus.
- Strong commitment to a lab-based role, with a high level of comfort working in a hands-on capacity in a synthetic chemistry environment
Strong organizational skills and attention to detail, with the ability to manage multiple tasks and maintain accurate records of experimental work
- Excellent teamwork and communication skills, with the ability to work effectively with senior scientists and contribute to a collaborative research environment
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