Senior Scientist/Associate Director

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals' unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees. Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so. Does this inspire you and feel like a fit? Then we would love to have you join us The Role Quantitative Systems Pharmacology (QSP) Modeler will serve as the QSP lead on a number of pre-clinical and clinical development programs. The individual will oversee all aspects of QSP strategies for candidate drug products from early development through late stage development using model-based approaches to improve the efficiency of drug development, and improve our mechanistic understanding, and to support dose selection of clinical candidates. This position's primary role is to develop and implement QSP models, supporting the development of novel therapies including antibody-drug conjugates (ADC), bispecific antibodies, immuno-oncology agents, and other mechanisms. The successful candidate will collaborate with discovery, preclinical, translational and clinical development as well as other scientists in the Translational and Quantitative Sciences group to develop mathematical models and help understand targeted biological pathways and interactions of novel therapeutic modalities. The candidate is responsible for framing critical questions to establish the right modeling & simulation strategies that enable lead optimization, identify PK/PD relationships, inform dose selection and Go/No Go decisions by utilizing mechanistic QSP models. Essential qualifications include in-depth understanding of cell biology ─ particularly in immunology and oncology ─ and numerical methods, as well as hands‑on experience with modeling software, ability to clearly present modeling and simulation findings, and demonstrate ability to thrive in a matrix environment working at the leading edge of technologies. The candidate will design and build models based on preclinical and emerging clinical data as well as leveraging literature sources of data and relevant immuno‑oncology and oncology knowledge. The candidate will cultivate data in support of model construction and interpretation, define key issues, and provide simulations of disease, mechanism of action, and (non)clinical studies. The candidate should be driven to use all tools at their disposal (QSP, PK/PD, Machine Learning (ML) and Artificial Intelligence (AI)) to understand the clinical pharmacokinetics and pharmacodynamics of novel drug candidates. The candidate will contribute to best practices on application of QSP and other mathematical or statistical analyses (e.g. artificial intelligence, machine learning, deep learning) across the clinical pharmacology group. This is an exciting opportunity to be part of a passionate, high profile, high‑impact Clinical Pharmacology team, and work in a highly dynamic and collaborative setting. Skills & Experience Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, immunology, pharmaceutical sciences, mathematics, statistics, or equivalent area with 2-5 years of industry and/or academic experience in mathematical modeling of biological systems. Job title is flexible based on experience. Strong competency in applying modeling and simulation related software such as Matlab/SimBiology, Julia, or other domain‑specific languages is required. Proficiency with systems modeling approaches such as ordinary, partial, and/or stochastic differential equations, boolean, agent‑based, or other advanced mechanistic modeling approaches is essential. Understanding of PK/PD analysis and translational modeling of preclinical PK/PD data, and mechanism‑based PK/PD systems using preclinical and/or clinical data with biologics therapeutics is also required Demonstrated ability and experience in applying modeling and simulation approaches to enable rational and efficient preclinical and clinical drug development are required Demonstrated ability to present results at cross‑functional teams, department meetings, review committees, and conferences. Extensive experience and strong understanding of oncology drug development is preferred Experience in Machine Learning/Artificial Intelligence is preferred Flexible, with positive attitude, ability to work with multidisciplinary teams, prioritize projects effectively and communicate at all levels within the company Excellent written, verbal and interpersonal communication skills Domestic and international travel will be required. Other Genmab employees work with determination and with respect for each other, consistent with our core values, to achieve our common goals. We give individuals and teams the autonomy to drive development of innovative products and solutions, knowing that integrity is a core value throughout our company. Genmab will offer the successful application a challenging position, where the right candidate will have the opportunity to work with highly specialized people across functions in an informal, multicultural culture, all aiming to make a difference for cancer patients. Teamwork and respect are central pillars of Genmab's culture, and we therefore ensure an inclusive, open, and supportive professional work environment across our international locations. We believe that fostering workplace diversity across social, educational, cultural, national, age and gender lines is a prerequisite for the continued success of the company. We are committed to diversity at all levels of the company and strive to recruit employees with the right skills and competences, regardless of gender, age, ethnicity, etc. Benefits For US based candidates, the proposed salary band for this position is as follows: $123,360.00---$185,040.00 The actual salary offer will carefully consider a wide range of factors, including your skills, qualifications, experience, and location. Also, certain positions are eligible for additional forms of compensation, such as discretionary bonuses and long‑term incentives. When you join Genmab, you're joining a culture that supports your physical, financial, social, and emotional wellness. Within the first year, regular full‑time U.S. employees are eligible for: 401(k) Plan: 100% match on the first 6% of contributions Health Benefits: Two medical plan options (including HDHP with HSA), dental, and vision insurance Voluntary Plans: Critical illness, accident, and hospital indemnity insurance Time Off: Paid vacation, sick leave, holidays, and 12 weeks of discretionary paid parental leave Support Resources: Access to child and adult backup care, family support programs, financial wellness tools, and emotional well‑being support Additional Perks: Commuter benefits, tuition reimbursement, and a Lifestyle Spending Account for wellness and personal expenses About You You are genuinely passionate about our purpose You bring precision and excellence to all that you do You believe in our rooted‑in‑science approach to problem‑solving You are a generous collaborator who can work in teams with a broad spectrum of backgrounds You take pride in enabling the best work of others on the team You can grapple with the unknown and be innovative You have experience working in a fast‑growing, dynamic company (or a strong desire to) You work hard and are not afraid to have a little fun while you do so Locations Genmab maximizes the efficiency of an agile working environment, when possible, for the betterment of employee work‑life balance. Our offices are crafted as open, community‑based spaces that work to connect employees while being immersed in our powerful laboratories. Whether you're in one of our office spaces or working remotely, we thrive on connecting with each other to innovate. About Genmab Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard‑working, innovative and collaborative team has invented next‑generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T‑cell engagers, antibody‑drug conjugates, next‑generation immune checkpoint modulators and effector function‑enhanced antibodies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock‑Your‑Socks‑Off (KYSO®) antibody medicines. Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X. Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com). Please note that if you are applying for a position in the Netherlands, Genmab's policy for all permanently budgeted hires in NL is initially to offer a fixed‑term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the fixed‑term employment contract. #J-18808-Ljbffr