Research Engineer I, Gastroenterology Research Medicine
3 weeks ago
We are seeking a Research Engineer, in the Traverso Lab at Brigham and Women's Hospital with a background in analytical chemistry. Our research group consists of an interdisciplinary team of engineers, chemists, biologists, pharmaceutical scientists, and physicians focused on developing clinically translatable biomedical devices and drug delivery systems.
The Research Engineer (analytical scientist) will be a member of the bioanalytics team with the following responsibilities:
* Operate LCMS, ELISA, PCR, GCMS, and ICP-MS equipment to analyze pre-clinical samples provided by formulation teams.
* Prepare pre-clinical LCMS and GCMS samples with high precision and quality.
* Develop bioanalytical methods for the detection of target molecules in complex matrices (plasma, serum, organ tissues, urine, etc).
* Design automated liquid handling programs for bioanalytical sample preparation, including: protein precipitation, solid phase extraction (SPE), and supported liquid extraction (SLE).
* Validate bioanalytical methods and evaluate the validation results against internal guidelines.
* Troubleshoot and repair analytical instrumentation, and/or coordinate onsite repair from OEM service provider.
* Write and prepare standard operating procedures.
* Support lead analytical chemists with requests, as needed.
* Manage sample tracking in LIMS.
* Document daily tasks and upload files to ELN.
B.S. (M.S. preferred) in a relevant scientific field (i.e. chemistry, biology, biochemistry, chemical engineering); at least two years' specialized experience (which may include experience gained as an undergraduate) with analytical chemistry; chromatography and mass spectrometry experience; experience working with and maintaining technical instruments/equipment; ability to multitask and organize multiple experiments and work assignments simultaneously and work both independently and as part of a team; strong time management, communication, and problem-solving skills; and awareness of basic safety issues and ability to follow safety procedures and maintain a safe work environment.
Candidate must have experience with chromatographic and mass spec instrumentation with prior experience in complex bioanalytical sample preparation. Familiarization with chemstation, OpenLab, Masshunter, and Analyst is a plus, and prior experience operating Agilent instrumentation is preferred. Individual must have basic mechanical capabilities and very strong independent problem solving capabilities.
Candidate must have self-motivation and willingness to learn new tools and techniques; strong organizational, interpersonal, and communication skills; ability to work independently and as part of a team; comfort summarizing and reporting results to interdisciplinary researchers; commitment to exceeding standards and producing accurate, high quality work; meticulous attention to detail; practiced documentation skills; and ability to follow safety procedures and maintain a safe work environment.
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Cambridge, United States Brigham and Women's Hospital Full timeGENERAL SUMMARY: The Research Engineer I will join the Traverso lab at Brigham and Women's Hospital to support translational development of novel therapeutic technologies. The lab consists of a multidisciplinary team of engineers, scientists and physicians focused on preclinical and translational development of drug delivery technologies that push the...
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Cambridge, United States Brigham and Women's Hospital Full timeGENERAL SUMMARY/ OVERVIEW STATEMENT: We are seeking a Research Engineer in the Traverso lab at Brigham and Women's Hospital with a background in material science and biomedical engineering. Our research group consists of chemists, biologists, engineers, pharmaceutical scientists, and physicians and focuses on developing clinically relevant solutions to a...
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