Senior Scientist

4 weeks ago

Exton, United States Frontage Lab Full time

Senior Method development scientist-Biomarker LC-MS/MS

Title: Senior method development scientist- Biomarker LC-MS/MS

Location: 700 Pennsylvania Dr. Exton, PA

Reports to: SVP, Central Lab, Biomarker, and Biologics Services

Full-time/on-site

Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position/Job Summary:

The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.

Roles & Responsibilities:

* Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, biomarkers, etc) quantitation in biological matrices.
* Facilitate the method transfer from the Method development team with the method validation team.
* Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.
* Ability to work on multiple projects at the same time.
* Research literature and external sources and identify new techniques and procedures that strengthen Frontage's capabilities.
* Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.
* Help with training and/or mentoring of junior scientific staff.
* Set-up, utilize, and maintain complex instrumentation Follow safety precautions.

Education, Experience & Skills Required:

* Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology or related scientific discipline.
* 6-10 years of direct experience of bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma or CRO industry.
* Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc.
* Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
* Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
* Proven ability to successfully work in a team environment. Excellent oral and written communication skills.
* Good knowledge and application of GLP with the ability to train technical personnel.
* Efficient time management.
* Strong troubleshooting and analytical skills.
* Detail oriented and meticulous.
* Ability to work independently under time constraints.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

  • Scientist/ Senior Scientist-Genomics

    1 month ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Scientists and Scientists - GenomicsFull TimeLocation-Exton, PAFrontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China....

  • Scientist/ Senior Scientist-Genomics

    1 month ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Scientists and Scientists - GenomicsFull TimeLocation-Exton, PAFrontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China....

  • Scientist/Senior Scientist

    2 weeks ago

    Exton, United States Frontage Lab Full time

    Scientist/Senior Scientist Full-Time Exton PA Frontage Laboratories Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We have enabled many...

  • Scientist/Senior Scientist

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior ScientistFull-TimeExton PA Frontage LaboratoriesFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We...

  • Scientist/Senior Scientist

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior ScientistFull-TimeExton PA Frontage LaboratoriesFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We...

  • Scientist/Senior Scientist, Pharmaceutical Analysis

    4 weeks ago

    Exton, United States Frontage Lab Full time

    Scientist/Senior Scientist - Pharmaceutical Analysis - Large Molecule Exton, PA (Research) Roles and Responsibilities: * Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analyze and characterize oligonucleotides, cell and gene products, biotherapeutic proteins, their conjugates, and...

  • Scientist/Senior Scientist, Pharmaceutical Analysis

    4 weeks ago

    Exton, United States Frontage Lab Full time

    Scientist/Senior Scientist - Pharmaceutical Analysis - Large MoleculeExton, PA (Research)Roles and Responsibilities:* Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analyze and characterize oligonucleotides, cell and gene products, biotherapeutic proteins, their conjugates, and...

  • Senior Scientist-Biomarker

    4 weeks ago

    Exton, United States Frontage Lab Full time

    Frontage Laboratories: Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage's core competencies include drug metabolism, pharmokinetics/ pharmacodynamics...

  • Scientist/Senior Scientist

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay/PotencyLocation: 760 Pennsylvania Drive, Exton, PA 19341Reports to: Sr Director BGC Therapy OperationsFull-timeFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization...

  • Scientist/Senior Scientist

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay/PotencyLocation: 760 Pennsylvania Drive, Exton, PA 19341Reports to: Sr Director BGC Therapy OperationsFull-timeFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization...

  • Senior Scientist-Biomarker

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionFrontage Laboratories:Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage’s core competencies include drug metabolism,...

  • Senior Scientist-Biomarker

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionFrontage Laboratories:Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage’s core competencies include drug metabolism,...

  • Senior Research Scientist, Antibody Engineering

    4 weeks ago

    Exton, United States Immunome Inc Full time

    Job title: Senior Research Scientist, Antibody EngineeringLocation: Exton, PAReports To: Senior Director, Antibody EngineeringAbout Us: Immunome is a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfolio pursues each target with a modality appropriate to its biology, including immunotherapies,...

  • Scientist/Senior Scientist, Pharmaceutical Analysis

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Pharmaceutical Analysis - Large MoleculeExton, PA (Research)Roles and Responsibilities:Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analyze and characterize oligonucleotides, cell and gene products, biotherapeutic proteins,...

  • Scientist/Senior Scientist, Pharmaceutical Analysis

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Pharmaceutical Analysis - Large MoleculeExton, PA (Research)Roles and Responsibilities:Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analyze and characterize oligonucleotides, cell and gene products, biotherapeutic proteins,...

  • Senior Scientist- Biologics

    4 weeks ago

    Exton, United States Frontage Lab Full time

    Senior Scientist - Biologics Full Time Exton PA Frontage Laboratories Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We have enabled many...

  • Senior Scientist

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Senior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MSLocation: 700 Pennsylvania Dr. Exton, PAReports to: SVP, Central Lab, Biomarker, and Biologics ServicesFull-time/on-siteFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization...

  • Senior Scientist

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MSLocation: 700 Pennsylvania Dr. Exton, PAReports to: SVP, Central Lab, Biomarker, and Biologics ServicesFull-time/on-siteFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service...

  • Senior Scientist

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MSLocation: 700 Pennsylvania Dr. Exton, PAReports to: SVP, Central Lab, Biomarker, and Biologics ServicesFull-time/on-siteFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service...

  • Senior Scientist- Biologics

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Scientist - BiologicsFull TimeExton PAFrontage LaboratoriesFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We...