Current jobs related to Senior Associate Scientist- Enzymology/Biochemistry - La Jolla - Pfizer
-
Senior Scientist
4 weeks ago
La Jolla, United States Pfizer Full timeWhy Patients Need YouEverything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through...
-
Senior Principal Scientist
3 weeks ago
La Jolla, United States Pfizer Full timeWhy Patients Need You Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Senior Principal Scientist
2 weeks ago
La Jolla, California, United States Pfizer Full timeAbout the RolePfizer's Oncology Research Unit in La Jolla, California, is seeking a Senior Principal Scientist to join the Tumor Immunity team. As a key member of the team, you will drive scientific strategies and their implementation to advance immuno-oncology programs within our pre-clinical portfolio.Key ResponsibilitiesLead research project teams to...
-
Senior Principal Research Scientist
3 weeks ago
La Jolla, California, United States Pfizer Full timePfizer's Oncology Research Unit is seeking a Senior Principal Scientist to join the Tumor Immunity team. As a key member of the team, you will be responsible for delivering breakthroughs that change patients' lives by redirecting the immune system against cancer. This is an exciting opportunity to leverage your expertise in Research and Development to drive...
-
Senior Scientist
3 weeks ago
La Jolla, United States Pfizer Full timeRole Summary Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Scientist (PhD) to join the Post-Candidate Research (PCR) group, focused on translating basic discoveries in the field of immune oncology (IO) into novel therapeutics. The Senior Scientist will serve as a technical subject matter expert and scientific...
-
Senior Principal Scientist
2 weeks ago
La Jolla, United States Pfizer Full timeWhy Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Scientist
4 days ago
La Jolla, United States Pfizer Full timeROLE SUMMARY You will translate basic discoveries in cancer biology into novel therapeutics.You will utilize cutting-edge chemical and biological tools to support our pre-clinical drug discovery programs. You will design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their...
-
Senior Principal Scientist, Cancer Cell Programs
2 weeks ago
La Jolla, California, United States Pfizer Full timeROLE SUMMARYPfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in cancer cell biology into novel therapeutics.Key ResponsibilitiesLead preclinical research with a collaborative team of scientists to advance clinical and...
-
Senior Pharmacovigilance Associate
3 days ago
La Jolla, California, United States Allen Spolden Full timeJob Title: Senior Pharmacovigilance AssociateAt Allen Spolden, we are seeking a highly skilled Senior Pharmacovigilance Associate to join our team. As a key member of our Pharmacovigilance department, you will play a critical role in ensuring the quality and accuracy of adverse event reports.Key Responsibilities:Ensure the quality and accuracy of adverse...
-
La Jolla, United States Pfizer Full timeROLE SUMMARY •T he overall role of the Oncology Early Stage [OES] Clinical Scientist (Senior Manger, non-MD) is to work collaboratively with the Global Development Lead (and members of the development team) to establish, lead, coordinate, and execute the early oncology clinical development plan(s) for one or more novel biological or small molecule...
-
Scientist (non
3 weeks ago
La Jolla, United States Pfizer Full timeROLE SUMMARY Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a self-motivated and collaborative Scientist (non-PhD) to join the Post-CAN research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics. The Scientist will participate in conducting preclinical research on our...
-
Senior Scientist, Proteomics
3 days ago
La Jolla, United States Pfizer Full timeWhy Patients Need YouAt Pfizer we deliver breakthroughs that change patients' lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells. The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of...
-
Senior Scientist
3 weeks ago
La Jolla, United States Pfizer Full timeRole SummaryPfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Scientist (PhD) to join the Post-Candidate Research (PCR) group, focused on translating basic discoveries in the field of immune oncology (IO) into novel therapeutics.The Senior Scientist will serve as a technical subject matter expert and scientific contributor,...
-
Senior Scientist, Proteomics
6 days ago
La Jolla, United States Pfizer Full timeWhy Patients Need You At Pfizer we deliver breakthroughs that change patients' lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells. The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of...
-
Senior Principal Scientist Tumor Biology
2 weeks ago
La Jolla, California, United States Pfizer Full timeJob SummaryThe Senior Principal Scientist Tumor Biology position is a critical role in our Oncogenic Transcriptional Networks team, focusing on translating basic discoveries in cancer epigenetics and oncogenic transcriptional programming into novel therapeutics.Key ResponsibilitiesLead a laboratory research group to study genetic and epigenetic mechanisms in...
-
Senior Principal Scientist Tumor Biology
1 week ago
La Jolla, California, United States Pfizer Full timeJob SummaryThe Senior Principal Scientist Tumor Biology position is a critical role in our Oncogenic Transcriptional Networks team, focusing on translating basic discoveries in cancer epigenetics and oncogenic transcriptional programming into novel therapeutics.Key ResponsibilitiesLead a laboratory research group to study genetic and epigenetic mechanisms in...
-
Scientist, Proteomics
4 weeks ago
La Jolla, United States Pfizer Full timeROLE SUMMARYAt Pfizer we deliver breakthroughs that change patients' lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells.The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of antibody-drug...
-
RD Associate Scientist
3 weeks ago
La Vista, United States Streck LLC Full timeJob DescriptionJob DescriptionStreck is seeking candidates for an R&D Associate Scientist 1 role to work with our scientific professionals on product enhancements and new product development. This position will primarily work within the scope of Biochemistry, chemistry, biology as it relates to the medical field and products. Candidates with a bachelor’s...
-
Senior Principal Scientist, Cancer Cell Programs
1 month ago
La Jolla, United States Pfizer Full timeROLE SUMMARYPfizer's Oncology Research Unit (ORU) unit in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.The Senior Principal Scientist will lead preclinical research with a collaborative team of...
-
La Jolla, United States Pfizer Full timeROLE SUMMARY Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a self-motivated and collaborative Scientist (non-PhD) to join the Post-CAN research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.The Scientist will participate in conducting preclinical research on our...
Senior Associate Scientist- Enzymology/Biochemistry
4 months ago
ROLE SUMMARY
The Biochemistry Department of Pfizer Oncology Research in La Jolla, CA is seeking a full time scientist to join our drug discovery team.
The enzymologist/biochemist will make important contributions to the discovery and pre-clinical development of oncology therapeutics, and will contribute to our molecular and biochemical understanding of enzymes that mediate epigenetic modifications of histone proteins and DNA. The scientist will be actively engaged in drug discovery activities for modulators of epigenetic targets, including the characterization of epigenetic enzymes and their inhibitors as well as histone and DNA methylation profiling and selectivity screening. In particular, the biochemist will be responsible for the development and validation of robust, reproducible plate-based enzyme assays. This will include kinetic and mechanistic studies to characterize enzyme targets, biochemical pathways, and mechanism of action of lead compounds.
The candidate will be responsible for testing compounds in biochemical assays, data analysis, and proper database publication of data. The candidate will participate on project teams, providing insight and technical expertise required for project progression. The individual will work closely with cell biologists and medicinal chemists, and apply strong biochemistry knowledge/skills to oncology small molecule drug discovery and development of innovative therapies.
ROLE RESPONSIBILITIES
A successful candidate will be required to develop and execute kinetic and mechanistic enzyme assays to understand epigenetic protein targets, their function and regulation, along with determining mechanism and binding site location of inhibitors, and protein/ligand SAR. The candidate will also be responsible for the development and performance of robust, automated biochemical assays for support of a cancer epigenetic drug discovery platform.
Participation on multi-disciplinary project teams, including oral presentation of results, and contribution to the understanding of the biochemical pathways associated with tumor epigenetic changes associated with tumor development and progression is also expected.
QUALIFICATIONS
* BS/MS Enzymologist/Biochemist with two or more years of experience in understanding the enzymes and proteins associated with cancer epigenetics.
* Experience in the development of assays and bioanalytical methods for studying enzyme activity and mechanism and for evaluating inhibitor potency and mechanism.
* Must have strong technical abilities; be skilled in the biochemical evaluation of enzymes including enzyme kinetics and in the development of automated plate-based biochemical assays.
* Strong interpersonal and communication skills required.
* Preference given to candidates with pharmaceutical/biotech drug discovery experience in evaluating small-molecule inhibitors against epigenetic enzyme targets such as histone methyltransferase or histone deacetylases and candidates with experience in Mass Spectrometry.
PHYSICAL/MENTAL REQUIREMENTS
* Must be able to work at a lab bench.
* Work with standard radioactive materials (3H, 32P, etc).
* Experience in enzyme kinetics and mathematical modeling strongly preferred.
Additional Information:
* Work Location Assignment: On Premise
* Eligible for Employee Referral
* Last Day to Apply: May 21, 2024
The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
