Senior Scientist, Translational Genomics

4 weeks ago

Waltham, United States AstraZeneca PLC Full time

Title: Senior Scientist, Translational Genomics - Haematology R & D

Location: AstraZeneca Boston R&D Site in Waltham, MA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are more than one of the world's leading pharmaceutical companies.

AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.

Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs

The Translational Medicine function exists within Haematology R&D to ensure effective and strategic biomarker studies for Haematology & Oncology project teams. Closely interacting with the pre-clinical Discovery, Early Clinical Development, and Precision Medicine & Biosamples diagnostics functions, Haematology Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all Haematology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement.

Functioning within the Early Oncology Genomics Team, the Haematology Translational Genomics scientists leverages Next Generation Sequencing (NGS) to contribute to translational oncology efforts. The successful candidate will handle large cohorts of patient samples, generate high-quality genomic data on Illumina sequencers, perform basic QC and data analysis, and maintain compliance with regulatory standards while keeping precise laboratory records.

Key Responsibilities and Accountabilities

* Perform NGS assays platforms on patient samples to support clinical trial exploratory endpoints
* Documentation of sample chain of custody and experimental work in Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN) to ensure compliance with AstraZeneca regulatory standards
* Follow laboratory standard operating procedures (SOPs) for established processes
* Perform DNA and RNA extractions on a variety of tissues including Formalin Fixed, Paraffin Embedded tissue, Fresh Frozen Tissue, Plasma and Blood
* Perform a variety of library preparation techniques including Whole Genome, Exome, Targeted Gene Panels, Methylome and Whole Transcriptome and associated barcoding strategies/methodologies.
* Perform sequencing on an Illumina NovaSeq X Plus instrument
* Work with informatics partners to QC and deliver sequencing data and assist bioinformaticians for data interpretation
* Operate automation platforms including ThermoFisher KingFisher Flex instruments and Beckman Coulter Liquid Handlers

Minimum Requirements

* Ph.D. degree or Master's plus 2+ years experience with a degree in a relevant field
* At least 2-3 years of experience with NGS Sequencing is essential
* Experience with nucleic acid extractions and library preparation
* Excellent written and verbal communication skills
* Strong analytical skills and experience with data analysis and interpretation
* Ability to work collaboratively in a team-oriented environment
* Ability to follow laboratory standard operating procedures (SOPs) and maintain accurate records of laboratory activities
* Ability to multi-task in a fast-paced environment with changing priorities
* Experience in working within a CLIA, CAP regulated laboratory is desirable
* Demonstrable knowledge of hematologic malignancies, including mutational drivers, experience with patient sample types current treatment options, and mechanisms of resistance is desirable

Preferred experience

* Experience with single cell or spatial sequencing.

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.

Our Waltham site offers a variety of amenities help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

"When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world."

Date Posted

29-Apr-2024

Closing Date

06-May-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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