Senior Scientist, Bioinformatics

4 weeks ago

Waltham Massachusetts, Middlesex County, MA, United States CSL Seqirus Full time

We have an exciting opportunity available for Senior Scientist, Bioinformatics & Data science, to join our Biopharmaceutical Product Development (BPD) department to shape the data analytics infrastructure, lead RNA-centric bioinformatics pipeline development and transform next-generation sequencing (NGS) data to therapeutics discovery.

As the first bioinformatician you will work onsite at the CSL Waltham site. You will lead all the bioinformatics activities supporting the development of self-amplifying mRNA (sa-mRNA) platform technology and next-generation process. You will also work with with Flu Cell Culture (FCC) development subject matter experts and in doing so, contributing to the advancement of FCC programs.

Our benefits include an Onsite gym, cafeteria, barista coffee bar, free onsite parking and bike storage, access to Medical, Dental, Vision, Life Insurance, 401K with a 6% match and an annual bonus; and accrued PTO, wellness days and floating holidays. This role can be flexible with 1-2 days WFH

Main Responsibilities

  • Build end-to-end bioinformatics pipelines for automated NGS data analysis and support sa-mRNA structure and stability assay development.
  • Perform statistical analysis on different types of NGS datasets and extract sa-mRNA structural and stability information at nucleotide-resolution.
  • Delivering bioinformatic and machine learning solutions to generate models for sa-mRNA sequence-to-function and sequence-to-process fitness prediction and contribute to the iterative design-testing cycle of sa-mRNA sequence optimization.
  • Collaborate with bioinformaticians and data scientists with expertise in various -omics, imaging, and high throughput screening technologies in the global CSL network, to build bioinformatic platform and advance computational genomics research at CSL Waltham.
  • Work closely with a fast-growing team of biochemists, molecular biologists, cell biologists, virologists, and chemical engineers to deliver product strategies, data science plans and project goals focused on mRNA sequence design and viral stock screening, with the possibility of supporting cell therapy and gene therapy product development.
  • Collaborating with peer functions to establish and manage an integrative outsourcing strategy to work with external genomic and bioinformatic commercial partners.
  • Stay up to date with the latest advancements in the fields of RNA therapeutics and bioinformatics, integrate new techniques where appropriate.

Qualifications:

You will report to Associated Director, Molecular Biology in BPD with a dotted line to the Director, Head of Bioinformatics & AI in the Global Research Data Science group, to be successful, you will have:

  • PhD in a relevant field such as bioinformatics, computational biology, or computer science (a master's degree with extensive industry experience will be considered).
  • Minimum 4 years of post-graduate RNA research and development experience in industry and/or academic environment.
  • Extensive experience with the analysis of short-read and long-read sequencing data to interpret RNA structure, translation, and stability properties.
  • Experience in mRNA sequence design with desired molecular features and properties using advanced machine learning is highly desired.
  • Experience with developing scalable bioinformatic workflows and pipelines to automate NGS data analysis following best practices of research software development.
  • Experience with applying advanced statistical, bioinformatic methods and machine learning algorithms to analyze genomic datasets and collaborating with biologists to draw statistically sound biological insights from experimental data.
  • Experience with working in a Unix-like and high-performance computing (HPC) environment on-premises and/or in the cloud using Python, R and other scientific computing languages.
  • Track record of publications and presentations at national and international conferences and industry events.

#LI-Onsite

Our Benefits

CSL Seqirus employees that work at least 30 hours per week are eligible for benefits effective day 1. We are committed to the wellbeing of our employees and their loved ones. CSL Seqirus offers resources and benefits, from health care to financial protection, so you can focus on doing work that matters. Our benefits are designed to support the needs of our employees at every stage of their life. Whether you are considering starting a family, need help paying for emergency back up care or summer camp, looking for mental health resources, planning for your financial future, or supporting your favorite charity with a matching contribution, CSL Seqirus has many benefits to help achieve your goals.

Please take the time to review our benefits site to see what’s available to you as a CSL Seqirus employee.

About CSL Seqirus CSL Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, CSL Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about CSL Seqirus.

We want CSL Seqirus to reflect the world around us

As a global organization with employees in 35+ countries, CSL embraces diversity and inclusion. Learn more about Diversity & Inclusion at CSL Seqirus.

Do work that matters at CSL Seqirus

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