Neuroscience Biology Lead

2 weeks ago

Boston, United States Manifold Bio Full time

Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position

Manifold Bio is seeking an enthusiastic, highly creative neuroscience lead to expand our drug discovery efforts. You will work closely with the founders and R&D leadership to refine our neuroscience strategy and advance pipeline programs treating diseases of the CNS. The ideal candidate will have a strong scientific background and experience leading biologics programs in one or more CNS therapeutic areas (neurodegeneration, neuroinflammation, neuro-oncology, etc). This is a unique opportunity to work with world-class technologists innovating in cutting edge molecular biology and compute approaches to realize the potential of a novel protein engineering platform. You will lead early discovery projects that integrate our novel platform capabilities with both internal and external R&D resources. Together, we'll continue to fundamentally change the current paradigm of drug development through the original vision of massively increasing the throughput of testing protein therapeutics.

Responsibilities

* Guide company level neuroscience / CNS strategy
* Evaluate new project/target opportunities and propose POC experiments
* Leverage external resources and coordinate internal team members to lead projects from discovery to candidate selection
* Coordinate with protein engineering on binder discovery and/or evaluate in-licensing opportunities, considering tradeoffs among target presentation and relation to disease biology
* Design screening funnels that integrate our novel mDesign in vivo biologics design platform
* Analyze and interpret data to enable decision making
* Design development plans to early human PoC, including specifying DC nomination criteria

Required Qualifications

* Biology Ph.D. or equivalent experience
* Experience designing screening funnels leveraging both in vitro and in vivo assays with a focus on biologics ( 5-10 for Dir. level; 10+ for VP level)
* Previous experience as a team lead or co-lead in an industry setting
* Experience with hybrid drug discovery models blending external and internal R&D workflows
* Highly independent and proactive, excellent communication and cross-functional team coordination skills

Preferred Qualifications

* Experience with molecules that enhance BBB transcytosis (e.g. 'shuttles')
* Experience and interest in assay development (in vitro/ex vivo/in vivo)
* Experience with preclinical development and clinical trial planning

Why this might be a great role for you

* You are eager to solve the challenge of CNS delivery of biologics
* You love thinking about how to apply exciting new platforms
* You are excited about starting drug programs from the very beginning
* You want to join a small, agile, highly innovative team

We value different experiences and different ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

Benefits

Highly competitive additional benefits package across healthcare, paid time off, commuter benefits, and company-provided lunch every day.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

  • Scientist, Biology

    2 weeks ago

    Boston, United States Manifold Bio Full time

    Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding...

  • Director of Computational Biology

    4 weeks ago

    Boston, United States Harnham Full time

    About:This company's mission is to leverage the power of artificial intelligence and computational biology to accelerate the discovery of novel therapeutics and improve patient outcomes.Job Description:We are seeking a highly skilled and motivated Director of Computational Biology to lead our computational biology team in the development and application of...

  • Director of Computational Biology

    4 weeks ago

    Boston, United States Harnham Full time

    About:This company's mission is to leverage the power of artificial intelligence and computational biology to accelerate the discovery of novel therapeutics and improve patient outcomes.Job Description:We are seeking a highly skilled and motivated Director of Computational Biology to lead our computational biology team in the development and application of...

  • Director of Computational Biology

    4 weeks ago

    Boston, United States Harnham Full time

    About:This company's mission is to leverage the power of artificial intelligence and computational biology to accelerate the discovery of novel therapeutics and improve patient outcomes.Job Description:We are seeking a highly skilled and motivated Director of Computational Biology to lead our computational biology team in the development and application of...

  • Director of Computational Biology

    3 weeks ago

    Boston, United States Understanding Recruitment Full time

    Job Title: Director of Computational BiologyLocation: Boston, MACompany: A cutting-edge biotech firm at the forefront of proteomics research is seeking a talented and experienced Director of Computational Biology to join their dynamic team in Boston, MA. This company is dedicated to advancing the understanding of complex biological systems and developing...

  • Director of Computational Biology

    3 weeks ago

    Boston, United States Understanding Recruitment Full time

    Job Title: Director of Computational BiologyLocation: Boston, MACompany: A cutting-edge biotech firm at the forefront of proteomics research is seeking a talented and experienced Director of Computational Biology to join their dynamic team in Boston, MA. This company is dedicated to advancing the understanding of complex biological systems and developing...

  • Director of Computational Biology

    3 weeks ago

    Boston, United States Understanding Recruitment Full time

    Job Title: Director of Computational BiologyLocation: Boston, MACompany: A cutting-edge biotech firm at the forefront of proteomics research is seeking a talented and experienced Director of Computational Biology to join their dynamic team in Boston, MA. This company is dedicated to advancing the understanding of complex biological systems and developing...

  • Scientist II, Computational Biology

    6 days ago

    Boston, United States Foundation Medicine Full time

    About the Job The Scientist II, Computational Biology will work as part of a new product team, focused on improving blood-based cancer diagnostic capabilities in areas such as cancer detection, minimum residual disease, and other related applications. This team is comprised of talent from across the Roche ecosystem, including Roche Diagnostics, Roche Pharma...

  • Scientist II, Computational Biology

    2 weeks ago

    Boston, Massachusetts, United States Foundation Medicine Full time

    About the JobThe Scientist II, Computational Biology will work as part of a new product team, focused on improving blood-based cancer diagnostic capabilities in areas such as cancer detection, minimum residual disease, and other related applications. This team is comprised of talent from across the Roche ecosystem, including Roche Diagnostics, Roche Pharma...

  • Scientist II, Computational Biology

    3 weeks ago

    Boston, United States Foundation Medicine Full time

    About the Job The Scientist II, Computational Biology on the Computational Biology Team provides computational, bioinformatic and statistical activities to enrich the analytical capabilities of existing products as medical knowledge advances, as well as to design and build lab protocols and computational analyses for new products. Key...

  • Associate Director, Biology

    4 hours ago

    Boston, United States Nimbus Therapeutics Full time

    Nimbus has an outstanding opportunity for an exceptional Associate Director of Biology to join our team. The person in this role will take on a variety of responsibilities contributing to Nimbus' current, ongoing projects and strategy, as well as evaluation of potential new targets. This role will primarily support Nimbus' Immunology pipeline and will report...

  • Research Assistant I

    2 weeks ago

    Boston, United States Harvard University Full time

    College background and 1 years of relevant experience. Bachelors degree in biology or related discipline, a passion for neuroscience, 1 years of experience working in a research lab, and prior experience working with mice is strongly preferred. Self Research, Assistant, Technology, Education

  • Scientist II- Brain Targeting Program

    2 weeks ago

    Boston, United States Harvard University Full time

    About Us: The Wyss Institutes mission is to transform healthcare and the environment by emulating the way nature builds. We harness the imagination of academia and the focus of industry to translate ground-breaking technologies into commercial produ Scientist, Program, Chemistry, Neuroscience, Healthcare, Education, Technology, Biology

  • Research Assistant I

    1 week ago

    Boston, United States Harvard University Full time

    1 year previous lab experience. Advanced education may count towards experience. Bachelor's or Masters degree with prior experience in a wet lab environment. A major in Neuroscience, computer science, engineering or a biology-related subject is pref Research, Assistant, Technology, Education, Experience

  • Research Technician, Center for Genomic Medicine

    2 weeks ago

    Boston, United States Massachusetts General Hospital Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT: The Chemical Neurobiology Lab within the Massachusetts General Hospital's Center for Genomic Medicine and the Center for the Neuroscience of Psychedelics is currently seeking a highly motivated, talented and science enthusiastic Research Technician with a hands-on background in neurobiology, molecular biology, or a...

  • Research Technician

    1 day ago

    Boston, United States Massachusetts General Hospital(MGH) Full time

    **Research Technician** - (3289728) **GENERAL SUMMARY/ OVERVIEW STATEMENT**: **PRINCIPAL DUTIES AND RESPONSIBILITIES**: - Primary responsibility for management of knockout and transgenic mouse colonies - Isolation of genomic DNA from tail biopsies - Genotyping by PCR analysis - Assisting with mouse anesthesia and surgery - Immunohistochemistry - Tissue...

  • Lead, Machine Learning Engineering

    2 weeks ago

    Boston, United States 1910 Genetics Full time

    Company Overview  1910 Genetics is the only company that has built a synergistic, dual-purpose small and large molecule platform that integrates artificial intelligence (AI), computation, and biological automation to design drug-like molecules better, faster, and cheaper than traditional approaches.    Based in the Seaport District of Boston, 1910...

  • Scientist - RNA Therapeutic Discovery

    2 weeks ago

    Boston, United States ascidian therapeutics Full time

    About us: Ascidian is redefining the treatment of disease by rewriting RNA. Ascidian Therapeutics was founded to rewrite RNA by editing and replacing human exons. We were inspired by ocean creatures, called Ascidians, who are primordial ancestors of vertebrates. To grow from larvae to adults, ascidians re-engineer their transcriptome through RNA editing...

  • Senior Associate Scientist, DMPK

    4 weeks ago

    Boston, Massachusetts, United States Cerevel Therapeutics Full time

    Our portfolio of pre-commercial neuroscience assets targets a broad range of central nervous system (CNS) disorders, including schizophrenia, epilepsy, Parkinson's disease and substance use disorder.This is an exciting role for a Senior Associate lab scientist to be part of the growing DMPK (Bioanalytical) group here at Cerevel.The ideal candidate will be...

  • Principal Research Associate/Associate Scientist, Cell Biology

    2 weeks ago

    Boston, United States Magnet Biomedicine Full time

    Principal Research Associate/Associate Scientist, Cell Biology About Magnet Biomedicine Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a...