Data Scientist, Translational Data Science
3 weeks ago
This is an on-site position in Cambridge, MA.
What you will do:
Synthesize our data into actionable insights by supplying to the Translational teams any needed computational, statistical, machine learning or modeling capabilities needed to advance our clinical programs. Examples include:
- Computational strategies for disease endotyping from back-translational studies to identify and rank indications for first in-human-studies as well as identify actionable targets/combinations.
- Identification and qualification of biomarkers (e.g., selection, PD, efficacy biomarkers) and analysis of data from both our clinical and research effects
- Assessment of treatment effects from both RNA (e.g., bulk, single cell, TCR/BCR, and spatial) and protein modalities (e.g., CITE/REAP-Seq, mIF, and high dimensional flow cytometry
Develop and apply computational, AI/ML methods to analyze our multi-modal data. Examples include:
- Best practices for single cell methods including data imputation and normalization, bulk deconvolution, cell type/state analysis, cell-cell interaction/trajectory inference, reconstruction of cell type specific interactomes - cellphoneDB and spatial transcriptomic analysis and visualization
- Pipelines for data processing and QC including visualization and integrative analysis (e.g., Nextflow, Python, shell scripts) including but not limited to quality control, alignment, variant calling, annotation, deconvolution, etc.
- Generative AI models to integrate and to analyze multi-modal molecular as well as patient clinical data
- Interactive dashboards for data visualization and interpretation
What you will bring:
- Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields
- A minimum of 5-years research (academia or industry) experience
- First-hand experience in single cell sequencing analysis and data generation methods as well as the computing infrastructure and data management methods
- First-hand multi-parametric data mining experience for disease endotyping, target identification and biomarker analysis. For example, multivariate analysis; dimensionality reduction methods; parametric and non-parametric statistical methods; Bayesian statistics; pattern recognition or classification methods
- Expert level fluency in statistical programming using Python, R/bioconductor or equivalents.
- Demonstrated ability to lead projects of moderate scope, mapping-out critical path, milestones and timelines, as well as manage expectations with minimal supervision.
- Demonstrated experience in deep learning and generative AI model assessment is a differentiator.
- Curiosity to dive below the surface and proactively identify critical issues including their tactical and strategic resolutions.
- Excellent oral and written communication
Benefits we offer:
HiFiBiO is committed to the health and well-being of our team members and offers a variety of benefits supporting our diverse employee base. All full-time employees are eligible for our comprehensive benefits package:
- Medical, Dental, and Vision insurance (Company covers 80% of the premium cost)
- Life, AD&D, Short-term, and Long-term Disability Insurance (100% company covers)
- Health Savings Account & Flexible Spending Account
- Telehealth Service (100% company covers)
- Dependent Care Pre-tax Account
- Parking and Commuter Pre-tax Account
- Unlimited PTO (Paid Time Off)
10 Paid Holidays and Sick Time (40 hours per year) - 401(K) Plan
Equal Opportunity Employer
We are an Equal Opportunity Employer. Applicants and employees are considered for positions and evaluated without regard to mental or physical disability, race, color, religion, gender, national origin, age, genetic information, military or veteran status, sexual orientation, gender identity, gender expression, transgender status, marital status or any other protected Federal/National, State/Province, or Local status unrelated to the performance of the work involved.
Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)
Our Human Resources team manages the recruitment and employment process for HiFiBiO Therapeutics. To protect the interests of all parties involved, HiFiBiO will only accept resumes from a recruiter if an executed search agreement directed to the particular position(s) is in place. Unsolicited resumes sent to HiFiBiO from recruiters do not constitute any type of relationship between the recruiter and HiFiBiO and do not obligate HiFiBiO in any way to pay any fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees; no response will be provided to such contact or presentation.
About HiFiBiO Therapeutics
HiFiBiO is a clinical stage biotech company advancing a robust pipeline targeting both innate and adaptive immunity to treat cancer and autoimmune disease. Our proprietary and versatile DIS™ single-cell platform enables the rapid discovery of novel antibody therapeutics and predictive biomarkers through our internal development programs and strategic collaborations. Our passionate team across three continents embraces a fast-paced and engaging work environment to bring transformative medicines to patients.
-
Data Engineer
4 weeks ago
Cambridge, United States Catalytic Data Science Full timeJob DescriptionJob DescriptionSalary: Data EngineerEngineering REMOTE OPPORTUNITY About Catalytic Data Science (CDS):Catalytic Data Science is a groundbreaking cloud R&D platform designed to integrate the volumes of scientific resources, data, and analytic tools while providing the ability to network with colleagues in one secure and scalable...
-
Sr. Bioinformatics Scientist
1 month ago
Cambridge, United States Catalytic Data Science Full timeJob DescriptionJob DescriptionSalary: Sr. Bioinformatics Scientist About Catalytic Data Science (CDS): REMOTE OPPORTUNITY Catalytic Data Science is a groundbreaking cloud R&D platform designed to integrate the volumes of scientific resources, data, and analytic tools while providing the ability to network with colleagues in one secure and scalable...
-
Cambridge, United States Matchpoint Therapeutics Full timeMatchpoint is a biotechnology company harnessing the power of covalency to discover precision covalent medicines to transform the treatment of immune diseases and other serious illnesses. The company's proprietary Advanced Covalent Exploration (ACE) platform integrates advanced chemoproteomics, machine learning and covalent chemistry library evolution....
-
Senior Data Scientist
2 weeks ago
Cambridge, United States Eisai Inc. Full timeAt Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai’s human health care (hhc) mission. We’re a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development...
-
Translational Science Lead
1 day ago
Cambridge, United States Bayer Inc. Full timeAt Bayer we're visionaries, driven to solve the world's toughest challenges and striving for a world where 'Health for all Hunger for none' is no longer a dream, but a real possibility. We're doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and...
-
Data Scientist
1 month ago
Cambridge, United States ReviveMed Full timeReviveMed is an MIT spinout, AI-based metabolomic platform for precision medicine. Metabolites, small molecules such as glucose and cholesterol, offer crucial insights into disease, patient physiology, and immune system activity, but current platforms can only detect less than 5% of human metabolites, hindering biological discoveries. We have developed the...
-
Data Scientist
1 month ago
Cambridge, United States ReviveMed Full timeReviveMed is an MIT spinout, AI-based metabolomic platform for precision medicine. Metabolites, small molecules such as glucose and cholesterol, offer crucial insights into disease, patient physiology, and immune system activity, but current platforms can only detect less than 5% of human metabolites, hindering biological discoveries. We have developed the...
-
Data Scientist
1 month ago
Cambridge, United States ReviveMed Full timeReviveMed is an MIT spinout, AI-based metabolomic platform for precision medicine. Metabolites, small molecules such as glucose and cholesterol, offer crucial insights into disease, patient physiology, and immune system activity, but current platforms can only detect less than 5% of human metabolites, hindering biological discoveries. We have developed the...
-
Cambridge, Massachusetts, United States Biogen Full timeJob Description About This Role Translational In Vivo Sciences (TIVS) at Biogen is seeking a Senior Associate Scientist to join a cross-functional research effort to enhance the delivery of Biogen’s therapeutics to the central nervous system (CNS) and muscle. These efforts will be applied across multiple therapeutic areas in the neurological and...
-
Cambridge, United States Sana Biotechnology Full timeAbout the role Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. Sana is involved in developing gene and cell therapeutics for the treatment of a broad range of...
-
Cambridge, United States Novartis Full time**Summary**: About the role : Internal Job Title: Research Scientist II Job Location: Cambridge, MA onsite About the Role: Disease Area X, a department within the Biomedical Research (BR) group of Novartis, focuses on diseases of critical human organs, including kidney, lung, and liver. We are seeking a scientist to join our interdisciplinary pharmacology...
-
Front End Engineer
4 weeks ago
Cambridge, United States Catalytic Data Science Full timeJob DescriptionJob DescriptionSalary: Position: Front-End Engineer REMOTE OPPORTUNITY Who we are:Catalytic Data Science is a team of research scientists and technologists that felt there had to be a better way for the brightest minds in research to drive innovation. With the researcher's needs always at the forefront of our mission, we build digital...
-
Cambridge, Massachusetts, United States Sana Biotechnology Full timeAbout the roleSana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. Sana is involved in developing gene and cell therapeutics for the treatment of a broad range of...
-
Cambridge, United States Bayer Inc. Full timeAt Bayer we're visionaries, driven to solve the world's toughest challenges and striving for a world where 'Health for all Hunger for none' is no longer a dream, but a real possibility. We're doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and...
-
Bioinformatics Engineer
3 weeks ago
Cambridge, United States Catalytic Data Science Full timeJob DescriptionJob DescriptionSalary: Bioinformatics Engineer (SEII)About Catalytic Data Science (CDS): REMOTE OPPORTUNITY Catalytic Data Science is a groundbreaking cloud R&D platform designed to integrate the volumes of scientific resources, data, and analytic tools while providing the ability to network with colleagues in one secure and scalable...
-
Data Scientist
2 weeks ago
Cambridge, Massachusetts, United States Amgen Full timeAmgen is a biopharmaceutical leader founded on discovering, developing, manufacturing, and delivering innovative human therapeutics. The Attribute Sciences Data Engineering (ASDE) group applies scientific and technical engineering expertise in support of Amgen's pipeline and commercial portfolio. This team applies continuous verification principles and...
-
Principal Scientist, Translational Modeling
3 days ago
Cambridge, United States Novartis Full time**About the Role**: The position is located in Cambridge, MA and will not have the ability to be located remotely. LI-Hybrid About the role: We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human...
-
Genomic Data Coordinator
2 weeks ago
Cambridge, Massachusetts, United States Biogen Full timeJob Description About This Role In Biogen’s Translational Sciences group, we leverage cutting-edge data and insights from human genetics and genomics, multi-omics, disease biology, and real-world patient and population cohorts to identify, validate, and prioritize novel drug targets, and to advance pipeline programs towards clinical development up until...
-
Technical System Health Data Scientist
4 days ago
Cambridge, Massachusetts, United States Philips Full timeJob TitleTechnical System Health Data ScientistJob DescriptionTechnical System Health Data Scientist You will be responsible for working with technical experts and customers to develop advanced reports on patient monitoring system usage and system health. These reports will help customers and Philips understand usage, prevent downtime and achieve performance...
-
Sr. Scientist
4 weeks ago
Cambridge, Massachusetts, United States MOMA Therapeutics Full timeMOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational ChemistryUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity, and collaboration; and...