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Principal Associate Scientist, Pharmaceutical Sciences
4 months ago
Why join us?
FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.
FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. FogPharma is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. FogPharma has raised more than $500 million to date from leading life sciences investors. FogPharma is headquartered in Cambridge, Mass.
What's the opportunity?
In this role, you will partner with scientists across the organization to discover and develop the best HeliconTM peptides and tailor them to fit patients' needs. We are looking for an enthusiastic and innovative scientist to join a multidisciplinary team and help us discover and develop novel inhibitors of undruggable disease targets. Your role will report to the Senior Formulation Scientist and will be to support drug product development at FogPharma. This will require both hands-on and strategic approaches, leveraging internal and external capabilities with high flexibility. Ideal candidates will be experienced, energetic, and passionate, with a broad knowledge of parenteral formulation development. This position is primarily lab-based, and you will be a primary data generator with opportunities to influence and guide the formulation strategy for our investigative drugs.
* Support drug product development activities at FogPharma.
* Partner with early discovery through CMC to develop and implement fit-for-purpose formulations for our HeliconTM
* Leverage internal and external capabilities to advance our programs.
* Lead by example and take a hands-on approach to solving our most pressing challenges.
What you'll need to be successful:
* MS with 7+ years or BS with 10+years of industry experience in Formulation Development.
* Experience developing parenteral formulations to support preclinical research, candidate selection, and IND-enabling studies. Experience with clinical drug product development and manufacturing is a plus.
* Experience developing fit-for-purpose analytical methods to support formulation development, especially U/HPLC-based methods.
* Excellent communication, organization, strategic, and cross-functional team skills.
* Formulation and analytical experience with parenteral small molecules and/or biologics is preferred.
* Experience managing external vendors for formulation and analytical development is a plus.
* Experience with Quality Assurance, Quality systems, and GMP production is a plus.
* Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)
Core Values
FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.
* Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
* Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
* Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
* Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.
As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
