EPM Scientific | Scientist II, Immunology | san antonio, tx

2 days ago


san antonio, United States EPM Scientific Full time

General Summary:

The company is seeking a Scientist II, Immunology to oversee all scientific activities, including applied research, new product/service development, clinical trials, data analysis, and scientific publication. The candidate will ensure top-notch customer service, addressing feedback to resolve issues and enhance satisfaction.


Major Duties and Responsibilities:

  • Oversee research projects and manage research, development, and specialty projects, including clinical-trial support.
  • Conduct and supervise regenerative medicine-related research and analytical assays.
  • Train and supervise junior staff, implementing facility policies and procedures.
  • Perform meticulous record-keeping and maintain proficiency in mammalian cell culture, flow cytometry, and cell-based assays.
  • Conduct in vitro characterization of cell therapy products and utilize platforms to evaluate innate cell function.
  • Contribute to molecular biology methods for characterizing primary and engineered cells.
  • Design and perform in vitro biochemical and cell-based assays.
  • Develop preclinical assays for evaluating dysfunctional states.
  • Collaborate with cross-functional teams for IND-enabling and clinical Phase I/II-enabling activities.
  • Drive cell therapy upstream process development and support manufacturing troubleshooting and technology transfer activities.
  • Analyze and present data, troubleshoot experiments, and apply Quality by Design (QbD) methodology.


Education:

  • Master’s Degree in Immunology, Cell Biology, Molecular Biology, Biotechnology, Biology, or Bioengineering required.
  • Doctoral Degree (Ph.D. or equivalent) preferred.


Experience:

  • At least two years of hands-on experience with production and generation of CAR-T, CAR-NK, CAR-γδT, and/or TCR-T cell therapies/immunotherapies.
  • Strong understanding of innate cell biology and immune regulation pathways.
  • Hands on experience with CRISPR/Cas9 for gene editing strongly preferred
  • Experience with high-dimensional FACS, transcriptional or epigenetic assessment, and other single-cell analytics.
  • Knowledge of FlowJo, GraphPad, ImageJ, and mammalian cell expansion techniques.


Knowledge:

  • Understanding of cell-based therapeutics and applied regenerative medicine.
  • Knowledge of tissue and cell culture, molecular biology techniques, and laboratory sciences.
  • Familiarity with regulatory/quality compliance, cGMP, cGTP, and CLIA regulations



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