Current jobs related to Process Chemistry Senior Principal Scientist - Boston - Vertex Pharmaceuticals
-
Process Chemistry Senior Principal Scientist
2 months ago
Boston, United States Vertex Pharmaceuticals Incorporated Full timeJob DescriptionGeneral Summary:The successful candidate will possess a deep knowledge of process chemistry skills for the development of synthetic routes, with early and late-phase development experience and delivering drug substance under tight timelines. They will have a strong interest in laboratory work and will be key to driving the development of safe...
-
Process Chemistry Senior Principal Scientist
2 months ago
Boston, United States Vertex Pharmaceuticals Full timeJob Description General Summary:The successful candidate will possess a deep knowledge of process chemistry skills for the development of synthetic routes, with early and late-phase development experience and delivering drug substance under tight timelines. They will have a strong interest in laboratory work and will be key to driving the development of safe...
-
Boston, Massachusetts, United States CRISPR Therapeutics Full timeJob OverviewCRISPR Therapeutics is a pioneering biotech company at the forefront of gene editing and therapeutics. We are seeking a highly skilled Senior/Principal Scientist to join our team and contribute to the development of next-generation mRNA technology and therapeutics.Key ResponsibilitiesDrive the discovery of innovative RNA/LNP delivery technologies...
-
Associate Principal Scientist, NMR
1 month ago
Boston, United States Merck Sharp & Dohme Full timeJob Description Our Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking, state-of-the-art facilities and modern equipment. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like...
-
Boston, Massachusetts, United States K.A. Recruiting Full timeMedical Laboratory Scientist or Chemistry Medical Technologist Job OpportunityK.A. Recruiting is seeking a highly skilled Medical Laboratory Scientist or Chemistry Medical Technologist to join our team in Massachusetts. As a Medical Laboratory Scientist or Chemistry Medical Technologist, you will be responsible for performing laboratory tests and analyzing...
-
Senior Formulations Scientist
1 week ago
Boston, Massachusetts, United States Elektrofi Inc Full timeJob Title: Senior Formulations ScientistWe are seeking a highly skilled Senior Formulations Scientist to join our team at Elektrofi Inc. As a key member of our formulation development team, you will play a crucial role in the development of our ultra-high concentration microparticle suspension products.Key Responsibilities:Lead the development of novel,...
-
Boston, Massachusetts, United States KA Recruiting Inc. Full timeWe are seeking a highly skilled Medical Laboratory Scientist with expertise in chemistry to join our team at KA Recruiting Inc. in Massachusetts.This is a full-time and permanent opportunity with a days shift schedule.The ideal candidate will have a college degree and be ASCP certified with prior experience in a medical laboratory setting.We offer a...
-
Boston, Massachusetts, United States Frontier Medicines Full timeJob Title: Senior/Principal Scientist, Disease BiologyFrontier Medicines is seeking a highly skilled and experienced Senior/Principal Scientist to join our Disease Biology team. The successful candidate will play a key role in leading the biology efforts aimed at elucidating drug mechanism of action and pharmacology on high-priority pipeline projects.Key...
-
Senior Scientist
7 days ago
Boston, Massachusetts, United States Takeda Full timeAbout the RoleAt Takeda, we are a forward-thinking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. As a Senior Scientist - Analytical Development, you will provide and drive theoretical/conceptual input to the design, development, and execution of research assignments for a specific project or projects...
-
Senior Process Chemistry Director
4 days ago
Boston, Massachusetts, United States BioSpace, Inc. Full timeJob SummaryThe Associate Director, Process Chemistry will be responsible for the design, development and staffing of the RNAi Chemical Development capability at Dicerna and Novo Nordisk. This role will lead the development, optimization, and scale up of biocatalytic and traditional synthetic processes to successfully transfer production internally or at...
-
Scientist/Senior Scientist
2 weeks ago
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...
-
Scientist/Senior Scientist
1 week ago
boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...
-
Scientist/Senior Scientist
1 week ago
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...
-
Scientist/Senior Scientist
2 weeks ago
boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...
-
Scientist/Senior Scientist
2 weeks ago
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...
-
Principal Scientist, Preclinical Pharmacology
3 months ago
Boston, United States OSI Full timePrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Principal Scientist, Preclinical Pharmacology
2 weeks ago
Boston, United States OSI Full timePrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Principal Scientist, Preclinical Pharmacology
2 months ago
Boston, United States PepGen Full timePrincipal Scientist, Preclinical Pharmacology Position Summary PepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Medical Laboratory Scientist, Chemistry
3 weeks ago
Boston, United States Massachusetts General Hospital(MGH) Full timeMedical Laboratory Scientist3:00 PM to 11:30 PMWe're offering a generous sign on bonus of $10,000 come you to our team. Recognizing and valuing exceptional talent, we're eager to discuss the exciting details of this bonus during our interview process. The Medical Technologist in the Chemistry Lab performs chemical tests on patient specimens to...
-
Senior/Principal Scientist, Disease Biology
2 days ago
Boston, Massachusetts, United States Frontier Medicines Full timeJob DescriptionFrontier Medicines is seeking a highly motivated individual to fill the position of Senior or Principal Scientist to join our Disease Biology team. The successful candidate will play a leading role in leading the biology efforts aimed at elucidating drug mechanism of action and pharmacology on a high priority pipeline first-in-class projects....
Process Chemistry Senior Principal Scientist
3 months ago
Job Description
General Summary:
The successful candidate will possess a deep knowledge of process chemistry skills for the development of synthetic routes, with early and late-phase development experience and delivering drug substance under tight timelines. They will have a strong interest in laboratory work and will be key to driving the development of safe and scalable chemistry. They will spearhead the advancement of Vertex’s portfolio through personal laboratory effort as well as overseeing internal and external resources. They will leverage additional Vertex resources (high-throughput experimentation, engineering and material sciences, process safety, analytical, mutagenic impurity risk assessment, etc.) to assist in identifying and optimizing reaction conditions for key transformations. The successful candidate will represent process chemistry in cross-functional teams requiring good communication skills. They will have accountability for creating and developing a synthetic route to deliver active pharmaceutical ingredients (APIs) within a specification range fit for the phase of development and delivering the technology and materials to enable candidate progression through development. The Sr. Principal Scientist Process Chemistry will lead/participate in cross-functional technical teams within their field of expertise. They will also be responsible for mentoring internal process chemistry scientists and promoting the department through publications in peer-reviewed journals and participation in external conferences.
Key Responsibilities Include:
- Demonstrates advanced intellectual and technical leadership
- Familiar with early and late phase pharmaceutical development and regulatory expectations
- Work with Pharm Sci team to develop project strategy, timelines, and leverage technical skills as a Process Chemistry expert within Vertex.
- Individual lab work focused on developing safe, scalable processes
- Seek to employ state-of-the-art technologies, including flow chemistry, photochemistry, electrochemistry, computational and predictive tools
- Contribute directly to technology transfer to internal sites or external vendors
- Proactively identify and oversee vendors to gain access to technologies as needed to deliver pipeline
- Leverage cross-functional knowledge to guide pharmaceutical sciences teams on potential impact of decisions
- Assess data integrity to provide expert interpretation and recommendations to project teams and leadership
- Present synthetic and experimental plans clearly and persuasively to all parts of the organization.
- Recognized as a technical leader by the group and may mentor junior staff
- Author publications, patents, and regulatory submissions
Knowledge and Skills:
- Effectively manage CRO/CMO resources
- Maintain standards for all laboratory records, internal reports, patents, and external communications
- Establish and deliver on agreed timelines while integrating activities across various departments
- Draft process descriptions for the CMC section of regulatory documents for early development projects
- A track record of successfully achieving goals and solving problems in the pharma environment
- Knowledge and experience with fundamental understanding of mutagenic impurity formation and control
- Ability to communicate difficult concepts, ideas, and solutions to project teams and leadership
- Knowledge and understanding of regulatory factors and maintaining expert knowledge in chemistry
- Other duties as defined
Education and Experience:
- Bachelor's degree and 11+ years of experience or a Master's degree and 9+ years of experience or a PhD and 8+ years of experience in the pharmaceutical industry
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information:
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
#J-18808-Ljbffr