Principal Scientists, Research Informatics

4 weeks ago


San Diego, United States Excelon Solutions Full time
Job DescriptionJob Description

About The Role

A full-time Research Informatics Scientist with proven and extensive experience in single-cell/single nucleus transcriptomics studies in the brain is available at Neurocrine Biosciences in San Diego, California. The position will support animal model and cell culture studies integral to neuroscience drug development programs. A Ph.D. in bioinformatics or related disciplines plus 4+ years of experience that includes exposure to neuroscience and drug discovery is preferred. The initial focus of this position will be bioinformatic approaches using 10X Genomics and short-read sequencing of cells and/or nuclei from the brain with future expansion to RNA and DNA analyses that include long-read sequencing platforms.

_

Your Contributions (include, But Are Not Limited To)

  • Support 10X Genomics bioinformatics for cell clustering and gene ontology applications to drive data analyses of single brain cell and cell line datasets
  • Develop and customize new informatic approaches and pipelines
  • Access, manage and analyze large sequencing datasets for both RNA and DNA
  • Access, manage and analyze metadata including medical record datasets

Requirements

  • PhD and 4+ years of related experience
  • Expert experience and familiarity with processing 10X Genomics datasets
  • Experience with both short-read (Illumina) and long-read sequencing (Pacific Biosciences (PacBio) and/or Oxford Nanopore Technologies) and analysis is preferred.
  • Knowledge of next generation sequencing toolsets (fastqc, STAR, bwa, samtools, GATK, etc.)
  • Familiarity with NCBI, UCSC Genome browser, Integrated Genomics Viewer
  • Mastery of command line operations and Linux/Unix operating environments
  • Expertise with high performance computing clusters and their use in sequence analyses
  • Fluency in multiple computer languages including R, Python, BASH, Julia, MATLAB and extensive experience in coding
  • Experience customizing pipelines, algorithms, and quality control metrics for data analysis
  • Attention to detail with accuracy
  • Ability to communicate effectively in English and to work in a fast-paced environment
  • Strong social skills and ability to work with others


  • San Diego, United States RPM ReSearch Full time

    Job DescriptionJob DescriptionResearch Scientist/Study Director OcularDescription: We are seeking to find an accomplished Ocular Scientist with requirements of a broad knowledge of Ocular anatomy, physiology, and biochemistry to help develop and support in vivo models to screen small molecule, cell/gene therapy, as well as large molecule therapeutics and...


  • San Jose, United States Adobe, Inc. Full time

    Changing the world through digital experiences is what Adobes all about. We give everyonefrom emerging artists to global brandseverything they need to design and deliver exceptional digital experiences! Were passionate about empowering people to Research Scientist, Research, Principal, Scientist, Processing, Technology, Transportation


  • San Diego, United States RPM ReSearch Full time

    Job DescriptionJob DescriptionJob Title: Veterinary Research ScientistPrimary Responsibilities:This position requires a broad knowledge of the anatomy and physiology of small and large animals to help develop and support in vivo models to screen therapeutics and devices being developed for various disorders. Experience with surgical, dosing and sampling...


  • San Diego, United States BioPhase Full time

    Sr. or Principal Scientist, Translational Genetics The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally.Responsibilities:The Scientist will leverage extensive human...


  • San Diego, United States BioPhase Full time

    Sr. or Principal Scientist, Translational Genetics The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally.Responsibilities:The Scientist will leverage extensive human...


  • San Diego, United States BioPhase Full time

    Sr. or Principal Scientist, Translational Genetics The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally.Responsibilities:The Scientist will leverage extensive human...


  • San Francisco, United States R&D Partners Full time

    R&D Partners is seeking to hire a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Contractor) in San Franciscon, CA. Your main responsibilities as a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Con Scientist, Principal, Clinical Research, Spectrometry, Chemistry, Staffing


  • San Diego, California, United States Oculus Search Partners Full time

    Principal Scientist, Peptide Protein Chemistry Direct HirePrincipal Scientist, Peptide Protein Chemistry This BioPharma is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options.Proficient in all aspects of modern peptide synthesis, protein bioconjugation, peptide and protein...


  • San Diego, United States International Staffing Consultants, Inc. Full time

    Top Tier BioPharmaceutical company looking to add a Principal Scientist to their dynamic Pharmacometrics team. The Pharmacometrics Group applies a range of model informed drug development (MIDD) approaches to support early and late-stage development of small and large molecules. We are seeking a skilled and qualified industrial scientist who has experience...


  • San Diego, United States Crescent City Recruitment Group Full time

    Top Tier BioPharmaceutical company looking to add a Principal Scientist to their dynamic Pharmacometrics team. The Pharmacometrics Group applies a range of model informed drug development (MIDD) approaches to support early and late-stage development of small and large molecules. We are seeking a skilled and qualified industrial scientist who has experience...

  • Principal Scientist

    1 week ago


    South San Francisco, United States Life Science People Full time

    Job Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet medical needs, backed by substantial financial support, my client is poised to...

  • Principal Scientist

    1 month ago


    South San Francisco, United States Life Science People Full time

    Job Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet medical needs, backed by substantial financial support, my client is poised to...

  • Principal Scientist

    2 days ago


    South San Francisco, United States Life Science People Full time

    Job Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet medical needs, backed by substantial financial support, my client is poised to...


  • San Diego, California, United States Novartis Full time

    AD/Sr. Principal Scientist - CADDThe Computer-Aided Drug Discovery (CADD) group in San Diego is seeking an AD/Senior Principal Scientist to join our talented and innovative drug discovery team.Initiate drug discovery efforts by proposing novel targets / modalities, evaluating target druggability and executing in silico hit generation, triage and expansion...

  • Research Scientist

    4 weeks ago


    San Diego, California, United States Scripps Full time

    Scripps Health is committed to providing the best possible patient care, and research is a critical part of that mission.The Research Scientist will join the team at the Shiley Center for Orthopaedic Research and Education (SCORE).conducts cutting-edge biomedical research at the forefront of innovative solutions for musculoskeletal tissue repair.Develop and...


  • San Diego, California, United States UC San Diego Full time

    The University of California, San Diego, Department of Surgery ( is committed to academic excellence and diversity within the faculty, staff and student body and seeks to recruit Research Scientist(s) for the Divisions of Surgical Oncology and Surgical Sciences.The appointment will be at the Assistant Research Scientist level.Candidates must have a MD or...

  • Sr. Scientist

    2 weeks ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...

  • Sr. Scientist

    2 weeks ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...

  • Sr. Scientist

    4 days ago


    San Diego, United States Meet Full time

    Meet's partnered with an exciting and growing biotech in San Diego for a Senior Scientist / Principal Scientist Analytical Development!You'll be responsible for designing, executing, and reporting on the analytical development of small molecule chemistry experiments, degradation pathways, characterization, and stabilization techniques for ophthalmic and...


  • San Diego, United States RayzeBio Full time

    Job Title: Principal Scientist, BiologyLocation: San DiegoNH: R6BackgroundRayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted...