Senior Principal Scientist, Protein Analytics

2 weeks ago

Boston, United States Hillstar Bio Full time
Job DescriptionJob Description

Hillstar Bio, a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc).

Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and Systemic Lupus Erythematosus (SLE). CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). SLE on the other hand, affects an estimated 3 million adults worldwide, with symptoms affecting various organs including joints, kidneys, blood cells, brain, heart, and lungs. Existing treatment options for CAD and SLE have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, SLE, and potentially other serious autoimmune conditions with a common biological origin.

Join Hillstar Bio as a protein analytics leader overseeing antibody characterization, developability assessment and pre-formulation, and working with a skilled team towards achieving our first IND milestone. Establish platforms of antibody characterization, developability assessment, formulation, and protein QC. Develop and delineate distinctive protein analytics strategies of programs by corroboration with antibody discovery, antibody production and immunology groups.

This pivotal role offers opportunities to shape our company culture, contribute to organization growth, and make a significant impact on treatment of autoimmune disease to benefit patients. We seek an enthusiastic scientist with extensive hands-on experience, broad knowledge in a variety of advanced biophysical characterization techniques, and strong cross-functional collaborative mindset in a fast-paced environment.

Duties & Responsibilities include

• Provide expertise in biophysical and biochemical protein characterization and antibody developability/manufacturability assessment in all stages of antibody development.

• Lead development candidate (DC) nomination.

• Interpret results and communicate within Antibody Research and cross-functional colleagues for successful execution/completion of project.

• Identify, evaluate, and implement new and existing technologies to improve protein characterization capabilities, throughput, and quality.

• Maintain detailed laboratory notebooks and write SOPs.

• Monitor, maintain, and calibrate laboratory instruments and equipment.

• Proactively share skills and knowledge and train others on techniques and protocols.

Requirements

• MS or PhD in Biochemistry, Biology, or a related field with at least 5+ years (MS) or 2+ years (PhD) of relevant industrial experience in protein analytics and characterization

• Expertise in affinity determination and epitope binning using Octet, ELISA, and SPR.

• Strong hands-on experience in protein biophysical characterization techniques such as DSF, DSC, SEC-MALS, DLS, Octet, CE, icIEF, HPLC-based assays (SEC, HIC, IEX, etc.)

• Experience with ELISA-based specificity screening of mAbs (PSR, DNA, insulin, serum binding assays) is desirable.

• Experience with Flow cytometry is a plus.

• Master in the efficient execution of highly robust, reproducible, well-documented laboratory experiments and results reporting.

• Ability to establish and troubleshoot experiments.

• Excellent organizational and time-management skills with strong attention to detail is a must.

• Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.

Benefits

Hillstar Bio offers a competitive compensation and benefits package, including a competitive salary, equity, and a comprehensive benefits package.

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